TY - JOUR
T1 - Normal Reference Ranges for Echocardiography
T2 - Rationale, study design, and methodology (NORRE Study)
AU - Lancellotti, Patrizio
AU - Badano, Luigi P.
AU - Lang, Roberto M.
AU - Akhaladze, Natela
AU - Athanassopoulos, George D.
AU - Barone, Daniele
AU - Baroni, Monica
AU - Cardim, Nuno
AU - Gomez De Diego, Jose Juan
AU - Derumeaux, Genevieve
AU - Dulgheru, Raluca
AU - Edvardsen, Thor
AU - Galderisi, Maurizio
AU - Gonçalves, Alexandra
AU - Habib, Gilbert
AU - Hagendorff, Andreas
AU - Hristova, Krasimira
AU - Kou, Seisyou
AU - Lopez, Teresa
AU - Magne, Julien
AU - De La Morena, Gonzalo
AU - Popescu, Bogdan A.
AU - Penicka, Martin
AU - Rasit, Tolga
AU - Rodrigo Carbonero, Jose David
AU - Salustri, Alessandro
AU - Van De Veire, Nico
AU - Von Bardeleben, Ralph Stephan
AU - Vinereanu, Dragos
AU - Voigt, Jens Uwe
AU - Voilliot, Damien
AU - Zamorano, Jose Louis
AU - Donal, Erwan
AU - Maurer, Gerald
PY - 2013/4
Y1 - 2013/4
N2 - BackgroundAvailability of normative reference values for cardiac chamber dimensions, volumes, mass, and function is a prerequisite for the accurate application of echocardiography for both clinical and research purposes. However, due to the lack of consistency in current echocardiographic 'reference values', their use for clinical decision-making remains questionable.AimsThe aim of the 'Normal Reference Ranges for Echocardiography Study (NORRE Study)' is to obtain a set of 'normal values' for cardiac chamber geometry and function in a large cohort of healthy Caucasian individuals aged over a wide range of ages (25-75 years) using both conventional and advanced echocardiographic techniques.MethodsThe NORRE Study is a large prospective, observational multicentre study in which transthoracic echocardiographic studies will be acquired in 22 laboratories accredited by the European Association of Cardiovascular Imaging and in one laboratory in the USA accredited by ICAEL. The final sample size has been estimated in 1100 normal subjects in whom M-mode, 2D, and 3D imaging, colour Doppler, pulsed-wave Doppler, pulsed-wave tissue Doppler, and colour tissue Doppler imaging data will be obtained. All studies will be sent to a central echocardiographic core laboratory for quantitative analysis. Multiple studies will be performed for reproducibility analysis.ConclusionAfter completion of the NORRE Study, uniform reference limits according to age, gender, and anthropometric parameters will be available to standardize the quantitative interpretation of echocardiography.
AB - BackgroundAvailability of normative reference values for cardiac chamber dimensions, volumes, mass, and function is a prerequisite for the accurate application of echocardiography for both clinical and research purposes. However, due to the lack of consistency in current echocardiographic 'reference values', their use for clinical decision-making remains questionable.AimsThe aim of the 'Normal Reference Ranges for Echocardiography Study (NORRE Study)' is to obtain a set of 'normal values' for cardiac chamber geometry and function in a large cohort of healthy Caucasian individuals aged over a wide range of ages (25-75 years) using both conventional and advanced echocardiographic techniques.MethodsThe NORRE Study is a large prospective, observational multicentre study in which transthoracic echocardiographic studies will be acquired in 22 laboratories accredited by the European Association of Cardiovascular Imaging and in one laboratory in the USA accredited by ICAEL. The final sample size has been estimated in 1100 normal subjects in whom M-mode, 2D, and 3D imaging, colour Doppler, pulsed-wave Doppler, pulsed-wave tissue Doppler, and colour tissue Doppler imaging data will be obtained. All studies will be sent to a central echocardiographic core laboratory for quantitative analysis. Multiple studies will be performed for reproducibility analysis.ConclusionAfter completion of the NORRE Study, uniform reference limits according to age, gender, and anthropometric parameters will be available to standardize the quantitative interpretation of echocardiography.
KW - 2D and 3D echocardiography
KW - Cardiac mechanics
KW - Chamber size and function
KW - M-mode
KW - reference values
UR - https://www.scopus.com/pages/publications/84875174616
UR - https://www.scopus.com/pages/publications/84875174616#tab=citedBy
U2 - 10.1093/ehjci/jet008
DO - 10.1093/ehjci/jet008
M3 - Article
C2 - 23376837
AN - SCOPUS:84875174616
SN - 2047-2404
VL - 14
SP - 303
EP - 308
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
IS - 4
ER -