TY - JOUR
T1 - Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk nuclear test site
AU - Takeichi, Nobuo
AU - Hoshi, Masaharu
AU - Iida, Shozo
AU - Tanaka, Kimio
AU - Harada, Yuka
AU - Zhumadilov, Zhaxybay
AU - Chaizhunusova, Nailya
AU - Apsalikov, Kazbek N.
AU - Noso, Yoshihiro
AU - Inaba, Toshiya
AU - Tanaka, Kenichi
AU - Endo, Satoru
PY - 2006
Y1 - 2006
N2 - Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.
AB - Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.
KW - Apparent nuclear abnormalities (ANA)
KW - Chromosome aberrations
KW - Radiation effect
KW - Semipalatinsk nuclear test site (SNTS)
KW - Thyroid cells
UR - http://www.scopus.com/inward/record.url?scp=33645410060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645410060&partnerID=8YFLogxK
U2 - 10.1269/jrr.47.A171
DO - 10.1269/jrr.47.A171
M3 - Article
C2 - 16571934
AN - SCOPUS:33645410060
SN - 0449-3060
VL - 47
SP - A171-A177
JO - Journal of Radiation Research
JF - Journal of Radiation Research
IS - SUPPL. A
ER -