Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk nuclear test site

Nobuo Takeichi, Masaharu Hoshi, Shozo Iida, Kimio Tanaka, Yuka Harada, Zhaxybay Zhumadilov, Nailya Chaizhunusova, Kazbek N. Apsalikov, Yoshihiro Noso, Toshiya Inaba, Kenichi Tanaka, Satoru Endo

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.

Original languageEnglish
Pages (from-to)A171-A177
JournalJournal of Radiation Research
Volume47
Issue numberSUPPL. A
DOIs
Publication statusPublished - 2006

Keywords

  • Apparent nuclear abnormalities (ANA)
  • Chromosome aberrations
  • Radiation effect
  • Semipalatinsk nuclear test site (SNTS)
  • Thyroid cells

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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