Optical Fiber Biosensor Based on an Etched High-Scattering Fiber: Towards Reflector-Less Biosensors

Daniele Tosi; Arman Aitkulov; Carlo Molardi; Marzhan Sypabekova; Wilfried Blanc

doi:10.1109/MetroInd4.0IoT48571.2020.9138255

Optical Fiber Biosensor Based on an Etched High-Scattering Fiber: Towards Reflector-Less Biosensors

Daniele Tosi, Arman Aitkulov, Carlo Molardi, Marzhan Sypabekova, Wilfried Blanc

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We propose an optical fiber biosensor based on a minimalistic architecture, labelled 'reflector-less biosensor'. The sensing unit is simply a high-scattering fiber (doped with MgO nanoparticles), wet-etched in a hydrofluoric acid bath. The Rayleigh scattering signatures are detected in reflection, achieving a sensitivity up to over 10 nm/RIU (refractive index units). The system has been functionalized for thrombin biosensing, achieving a detection of tens of nanomolar concentrations.

Original language	English
Title of host publication	2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	260-263
Number of pages	4
ISBN (Electronic)	9781728148922
DOIs	https://doi.org/10.1109/MetroInd4.0IoT48571.2020.9138255
Publication status	Published - Jun 2020
Event	2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Roma, Italy Duration: Jun 3 2020 → Jun 5 2020

Publication series

Name	2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings

Conference

Conference	2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020
Country	Italy
City	Roma
Period	6/3/20 → 6/5/20

Keywords

optical backscatter reflectometry
optical fiber biosensor
Optical fiber sensor
Rayleigh scattering
refractive index sensor

ASJC Scopus subject areas

Artificial Intelligence
Computer Networks and Communications
Computer Science Applications
Electrical and Electronic Engineering
Safety, Risk, Reliability and Quality
Instrumentation

Access to Document

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Tosi, D., Aitkulov, A., Molardi, C., Sypabekova, M., & Blanc, W. (2020). Optical Fiber Biosensor Based on an Etched High-Scattering Fiber: Towards Reflector-Less Biosensors. In 2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings (pp. 260-263). [9138255] (2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MetroInd4.0IoT48571.2020.9138255

Optical Fiber Biosensor Based on an Etched High-Scattering Fiber : Towards Reflector-Less Biosensors. / Tosi, Daniele; Aitkulov, Arman; Molardi, Carlo ; Sypabekova, Marzhan; Blanc, Wilfried.

2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2020. p. 260-263 9138255 (2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tosi, D, Aitkulov, A, Molardi, C , Sypabekova, M & Blanc, W 2020, Optical Fiber Biosensor Based on an Etched High-Scattering Fiber: Towards Reflector-Less Biosensors. in 2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings., 9138255, 2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 260-263, 2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020, Roma, Italy, 6/3/20. https://doi.org/10.1109/MetroInd4.0IoT48571.2020.9138255

Tosi D, Aitkulov A, Molardi C , Sypabekova M, Blanc W. Optical Fiber Biosensor Based on an Etched High-Scattering Fiber: Towards Reflector-Less Biosensors. In 2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2020. p. 260-263. 9138255. (2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings). https://doi.org/10.1109/MetroInd4.0IoT48571.2020.9138255

Tosi, Daniele ; Aitkulov, Arman ; Molardi, Carlo ; Sypabekova, Marzhan ; Blanc, Wilfried. / Optical Fiber Biosensor Based on an Etched High-Scattering Fiber : Towards Reflector-Less Biosensors. 2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 260-263 (2020 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2020 - Proceedings).

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abstract = "We propose an optical fiber biosensor based on a minimalistic architecture, labelled 'reflector-less biosensor'. The sensing unit is simply a high-scattering fiber (doped with MgO nanoparticles), wet-etched in a hydrofluoric acid bath. The Rayleigh scattering signatures are detected in reflection, achieving a sensitivity up to over 10 nm/RIU (refractive index units). The system has been functionalized for thrombin biosensing, achieving a detection of tens of nanomolar concentrations.",

keywords = "optical backscatter reflectometry, optical fiber biosensor, Optical fiber sensor, Rayleigh scattering, refractive index sensor",

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