Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution

Edoardo Gino Macchi, Daniele Tosi, Giovanni Braschi, Mario Gallati, Alfredo Cigada, Giorgio Busca, Elfed Lewis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Radiofrequency thermal ablation (RFTA) induces a high-temperature field in a biological tissue having steep spatial (up to 6°C/mm) and temporal (up to 1°C/s) gradients. Applied in cancer care, RFTA produces a localized heating, cytotoxic for tumor cells, and is able to treat tumors with sizes up to 3 to 5 cm in diameter. The online measurement of temperature distribution at the RFTA point of care has been previously carried out with miniature thermocouples and optical fiber sensors, which exhibit problems of size, alteration of RFTA pattern, hysteresis, and sensor density worse than 1 sensor/cm. In this work, we apply a distributed temperature sensor (DTS) with a submillimeter spatial resolution for the monitoring of RFTA in porcine liver tissue. The DTS demodulates the chaotic Rayleigh backscattering pattern with an interferometric setup to obtain the real-time temperature distribution. A measurement chamber has been set up with the fiber crossing the tissue along different diameters. Several experiments have been carried out measuring the space-time evolution of temperature during RFTA. The present work showcases the temperature monitoring in RFTA with an unprecedented spatial resolution and is exportable to in vivo measurement; the acquired data can be particularly useful for the validation of RFTA computational models.

Original languageEnglish
Article number117004
JournalJournal of Biomedical Optics
Volume19
Issue number11
DOIs
Publication statusPublished - Nov 1 2014
Externally publishedYes

Fingerprint

Optical Fibers
Fiber optic sensors
Ablation
ablation
Temperature distribution
temperature distribution
Hot Temperature
optical fibers
Temperature
sensors
temperature sensors
Temperature sensors
Tissue
Tumors
tumors
spatial resolution
Point-of-Care Systems
Neoplasms
fibers
Monitoring

Keywords

  • Distributed temperature sensor
  • Ex vivo liver tissue
  • Fiber optic sensors
  • Radiofrequency thermal ablation
  • Rayleigh backscattering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Medicine(all)

Cite this

Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution. / Macchi, Edoardo Gino; Tosi, Daniele; Braschi, Giovanni; Gallati, Mario; Cigada, Alfredo; Busca, Giorgio; Lewis, Elfed.

In: Journal of Biomedical Optics, Vol. 19, No. 11, 117004, 01.11.2014.

Research output: Contribution to journalArticle

Macchi, Edoardo Gino ; Tosi, Daniele ; Braschi, Giovanni ; Gallati, Mario ; Cigada, Alfredo ; Busca, Giorgio ; Lewis, Elfed. / Optical fiber sensors-based temperature distribution measurement in ex vivo radiofrequency ablation with submillimeter resolution. In: Journal of Biomedical Optics. 2014 ; Vol. 19, No. 11.
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