TY - JOUR
T1 - Organochlorine pesticides exposure in female adolescents
T2 - potential impact on sexual hormones and interleukin-1 levels
AU - Bapayeva, Gauri
AU - Poddighe, Dimitri
AU - Terzic, Sanja
AU - Zhumadilova, Akmaral
AU - Kulbayeva, Saltanat
AU - Terzic, Milan
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/12/15
Y1 - 2018/12/15
N2 - The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10–17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). The main outcome was assessment of OCPs blood levels (correlating to pubertal development and sexual hormonal status) and IL-1 levels. The delayed sexual development and the hormonal profile in OCPs exposed female adolescents correlated to the blood levels of OCPs. Interestingly, serum IL-1α and IL-1β in girls living in contaminated areas correlated to OCPs blood levels as well. Both OCPs and IL-1 blood levels in exposed female adolescents resulted to be increased, but further research is required to establish if that might represent an additional factor contributing to puberty disorders and/or reproductive health issues.
AB - The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10–17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). The main outcome was assessment of OCPs blood levels (correlating to pubertal development and sexual hormonal status) and IL-1 levels. The delayed sexual development and the hormonal profile in OCPs exposed female adolescents correlated to the blood levels of OCPs. Interestingly, serum IL-1α and IL-1β in girls living in contaminated areas correlated to OCPs blood levels as well. Both OCPs and IL-1 blood levels in exposed female adolescents resulted to be increased, but further research is required to establish if that might represent an additional factor contributing to puberty disorders and/or reproductive health issues.
KW - IL-1
KW - Organochlorine pesticides
KW - Puberty
KW - Sexual hormones
UR - http://www.scopus.com/inward/record.url?scp=85058057507&partnerID=8YFLogxK
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U2 - 10.1007/s12026-018-9049-9
DO - 10.1007/s12026-018-9049-9
M3 - Article
C2 - 30519792
AN - SCOPUS:85058057507
SN - 0257-277X
VL - 66
SP - 756
EP - 760
JO - Immunologic Research
JF - Immunologic Research
IS - 6
ER -