Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels

Gauri Bapayeva, Dimitri Poddighe, Sanja Terzic, Akmaral Zhumadilova, Saltanat Kulbayeva, Milan Terzic

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10–17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). The main outcome was assessment of OCPs blood levels (correlating to pubertal development and sexual hormonal status) and IL-1 levels. The delayed sexual development and the hormonal profile in OCPs exposed female adolescents correlated to the blood levels of OCPs. Interestingly, serum IL-1α and IL-1β in girls living in contaminated areas correlated to OCPs blood levels as well. Both OCPs and IL-1 blood levels in exposed female adolescents resulted to be increased, but further research is required to establish if that might represent an additional factor contributing to puberty disorders and/or reproductive health issues.

Original languageEnglish
Pages (from-to)756-760
Number of pages5
JournalImmunologic Research
Volume66
Issue number6
DOIs
Publication statusPublished - Dec 15 2018

Fingerprint

Interleukin-1
Pesticides
Hormones
Sexual Development
Kazakhstan
Reproductive Health
Puberty
Cross-Sectional Studies
Outcome Assessment (Health Care)
Serum
Research

Keywords

  • IL-1
  • Organochlorine pesticides
  • Puberty
  • Sexual hormones

ASJC Scopus subject areas

  • Immunology

Cite this

Organochlorine pesticides exposure in female adolescents : potential impact on sexual hormones and interleukin-1 levels. / Bapayeva, Gauri; Poddighe, Dimitri; Terzic, Sanja; Zhumadilova, Akmaral; Kulbayeva, Saltanat; Terzic, Milan.

In: Immunologic Research, Vol. 66, No. 6, 15.12.2018, p. 756-760.

Research output: Contribution to journalArticle

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