Ovarian carcinoma after long-term ovulation induction - Reality or coincidence? A case report

M. M. Terzic, N. Ostojic, B. Velimirovic, N. Arsenovic, B. Stimec

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

During 1993/94 in a thirty-nine years-old woman there were 7 ovulation inductions with hMG/hCG followed by either artificial insemination or IVF-ET procedure. Complaints dated from that time. In September 1994 she was admitted for lower right abdominal pain which persisted and even worsened after treatment with antibiotics and chemotherapeutics. After preoperative evaluation adnexectomy was performed. Multilocular highly differentiated serous papillary cystadenocarcinoma was found, displaying moderate nuclear atypia and small areas of clear-cell differentiation, with foci of necrosis and stromal microinvasion. Elevated serum CA-125 levels at the time of operation slightly decreased four weeks after (from 145 IU/ml to 124 IU/ml). Serum concentrations of CA-125 were within normal range between 6th to 8th postoperative week. Nine weeks after operation severe metrorrhagia occurred and curettage was performed. Histological evaluation of the obtained material showed papillary cystadenocarcinoma endometrioides endometrii G1 NG1. Serum CA-125 were extremely elevated to the values of 1360 IU/ml. Hysterectomy, adnexectomy and omentectomy were performed. There were no apparent metastatic features during the operative procedure. CA-125 levels decreased to 110 IU/ml six weeks thereafter. From that time this tumor marker was regularly determined, and stayed within normal range. Rx, ultrasonographic and CT examination confirmed her well-being. This case report stress on the direct chronological relation between hormonal stimulation of previously unremarkable ovaries and development of ovarian carcinoma. In order to assess current knowledge of the potential excess risk of ovarian carcinomas associated with ovulation induction, a Medline search of the literature was performed. It was confirmed that up to December 1996 there are eleven cases of ovarian malignancies after ovulation induction. Our patient is the twelfth.

Original languageEnglish
Pages (from-to)36-39
Number of pages4
JournalZeitschrift fur Onkologie
Volume29
Issue number2
Publication statusPublished - Jan 1 1997
Externally publishedYes

Fingerprint

Ovulation Induction
Papillary Cystadenocarcinoma
Carcinoma
Reference Values
Serous Cystadenocarcinoma
Serum
Artificial Insemination
Metrorrhagia
Curettage
Operative Surgical Procedures
Tumor Biomarkers
Hysterectomy
Abdominal Pain
Cell Differentiation
Ovary
Necrosis
Anti-Bacterial Agents
Neoplasms
Therapeutics

Keywords

  • CA-125
  • ovarian carcinoma
  • ovulation induction

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ovarian carcinoma after long-term ovulation induction - Reality or coincidence? A case report. / Terzic, M. M.; Ostojic, N.; Velimirovic, B.; Arsenovic, N.; Stimec, B.

In: Zeitschrift fur Onkologie, Vol. 29, No. 2, 01.01.1997, p. 36-39.

Research output: Contribution to journalArticle

Terzic, MM, Ostojic, N, Velimirovic, B, Arsenovic, N & Stimec, B 1997, 'Ovarian carcinoma after long-term ovulation induction - Reality or coincidence? A case report', Zeitschrift fur Onkologie, vol. 29, no. 2, pp. 36-39.
Terzic, M. M. ; Ostojic, N. ; Velimirovic, B. ; Arsenovic, N. ; Stimec, B. / Ovarian carcinoma after long-term ovulation induction - Reality or coincidence? A case report. In: Zeitschrift fur Onkologie. 1997 ; Vol. 29, No. 2. pp. 36-39.
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