Over-expression of p53 nuclear oncoprotein in colorectal adenomas

M. Pignatelli, G. W H Stamp, G. Kafiri, D. Lane, W. F. Bodmer

Research output: Contribution to journalArticle

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Abstract

p53 is a nuclear phosphoprotein which controls normal cell growth. Normal p53 protein is undetectable by standard immunohistochemical staininig and the over-expression found in neoplastic cells correlates with the presence of point mutations of evolutionary conserved regions of the p53 gene. We examined the expression of p53 protein in a series of 36 colorectal adenomas (13 tubular, 17 tubulovillous, 6 villous) showing different degrees of dysplasia (11 mild, 19 moderate, 6 severe), 11 moderately differentiated adenocarcinomas (6 Duke's A, 4 Duke's B, 1 Duke's C) and 5 metaplastic polyps using the polyclonal antibody CM1 which recognises p53 protein in conventionally fixed and processed histological material. We found that 15 out of 36 colorectal adenomas showed p53 immunoreactivity, although in 4 positive cases (26%) the staining was very focal (

Original languageEnglish
Pages (from-to)683-688
Number of pages6
JournalInternational Journal of Cancer
Volume50
Issue number5
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Tumor Suppressor Protein p53
Adenoma
Proteins
Phosphoproteins
p53 Genes
Polyps
Point Mutation
Adenocarcinoma
Staining and Labeling
Antibodies
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pignatelli, M., Stamp, G. W. H., Kafiri, G., Lane, D., & Bodmer, W. F. (1992). Over-expression of p53 nuclear oncoprotein in colorectal adenomas. International Journal of Cancer, 50(5), 683-688.

Over-expression of p53 nuclear oncoprotein in colorectal adenomas. / Pignatelli, M.; Stamp, G. W H; Kafiri, G.; Lane, D.; Bodmer, W. F.

In: International Journal of Cancer, Vol. 50, No. 5, 1992, p. 683-688.

Research output: Contribution to journalArticle

Pignatelli, M, Stamp, GWH, Kafiri, G, Lane, D & Bodmer, WF 1992, 'Over-expression of p53 nuclear oncoprotein in colorectal adenomas', International Journal of Cancer, vol. 50, no. 5, pp. 683-688.
Pignatelli, M. ; Stamp, G. W H ; Kafiri, G. ; Lane, D. ; Bodmer, W. F. / Over-expression of p53 nuclear oncoprotein in colorectal adenomas. In: International Journal of Cancer. 1992 ; Vol. 50, No. 5. pp. 683-688.
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