Abstract
Background: DJ-1 is associated with recessive early onset Parkinson disease. Results: DJ-1 acts as a metal-binding protein, binding copper and mercury, and DJ-1, but not mutated clinical variants, protects cells against metal-induced cytotoxicity. Conclusion: Small genetic alterations in a central Parkinson disease protein can sensitize cells to metal-induced cell death. Significance: Genetic alterations in DJ-1 can sensitize cells to metal-induced cell death in Parkinson disease.
Original language | English |
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Pages (from-to) | 22809-22820 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 31 |
DOIs | |
Publication status | Published - Aug 2 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology