Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity

Benny Björkblom, Altynai Adilbayeva, Jodi Maple-Grødem, Dominik Piston, Mats Ökvist, Xiang Ming Xu, Cato Brede, Jan Petter Larsen, Simon Geir Møller

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

Background: DJ-1 is associated with recessive early onset Parkinson disease. Results: DJ-1 acts as a metal-binding protein, binding copper and mercury, and DJ-1, but not mutated clinical variants, protects cells against metal-induced cytotoxicity. Conclusion: Small genetic alterations in a central Parkinson disease protein can sensitize cells to metal-induced cell death. Significance: Genetic alterations in DJ-1 can sensitize cells to metal-induced cell death in Parkinson disease.

Original languageEnglish
Pages (from-to)22809-22820
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number31
DOIs
Publication statusPublished - Aug 2 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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