Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity

Benny Björkblom; Altynai Adilbayeva; Jodi Maple-Grødem; Dominik Piston; Mats Ökvist; Xiang Ming Xu; Cato Brede; Jan Petter Larsen; Simon Geir Møller

doi:10.1074/jbc.M113.482091

Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity

Benny Björkblom, Altynai Adilbayeva, Jodi Maple-Grødem, Dominik Piston, Mats Ökvist, Xiang Ming Xu, Cato Brede, Jan Petter Larsen, Simon Geir Møller

National Laboratory Astana

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50 Citations (Scopus)

Abstract

Background: DJ-1 is associated with recessive early onset Parkinson disease. Results: DJ-1 acts as a metal-binding protein, binding copper and mercury, and DJ-1, but not mutated clinical variants, protects cells against metal-induced cytotoxicity. Conclusion: Small genetic alterations in a central Parkinson disease protein can sensitize cells to metal-induced cell death. Significance: Genetic alterations in DJ-1 can sensitize cells to metal-induced cell death in Parkinson disease.

Original language	English
Pages (from-to)	22809-22820
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.482091
Publication status	Published - Aug 2 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. / Björkblom, Benny; Adilbayeva, Altynai; Maple-Grødem, Jodi; Piston, Dominik; Ökvist, Mats; Xu, Xiang Ming; Brede, Cato; Larsen, Jan Petter; Møller, Simon Geir.

In: Journal of Biological Chemistry, Vol. 288, No. 31, 02.08.2013, p. 22809-22820.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background: DJ-1 is associated with recessive early onset Parkinson disease. Results: DJ-1 acts as a metal-binding protein, binding copper and mercury, and DJ-1, but not mutated clinical variants, protects cells against metal-induced cytotoxicity. Conclusion: Small genetic alterations in a central Parkinson disease protein can sensitize cells to metal-induced cell death. Significance: Genetic alterations in DJ-1 can sensitize cells to metal-induced cell death in Parkinson disease.",

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AU - Maple-Grødem, Jodi

AU - Piston, Dominik

AU - Ökvist, Mats

AU - Xu, Xiang Ming

AU - Brede, Cato

AU - Larsen, Jan Petter

AU - Møller, Simon Geir

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AB - Background: DJ-1 is associated with recessive early onset Parkinson disease. Results: DJ-1 acts as a metal-binding protein, binding copper and mercury, and DJ-1, but not mutated clinical variants, protects cells against metal-induced cytotoxicity. Conclusion: Small genetic alterations in a central Parkinson disease protein can sensitize cells to metal-induced cell death. Significance: Genetic alterations in DJ-1 can sensitize cells to metal-induced cell death in Parkinson disease.

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Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity

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