Passive exposure to smoke results in defective interferon- production by adenoids in children with recurrent respiratory infections

Gian Luigi Marseglia, Maria Antonietta Avanzini, Silvia Caimmi, Davide Caimmi, Alessia Marseglia, Chiara Valsecchi, Dimitri Poddighe, Giorgio Ciprandi, Fabio Pagella, Catherine Klersy, Anna Maria Castellazzi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

There is evidence that exposure to passive smoke is associated with an increased susceptibility to respiratory infections. Indeed, cigarette smoke extracts may interfere with the immune system, even though the precise mechanism has not been fully understood yet. Recurrent respiratory infections may be sustained by a defective immune response. The aim of the present study was to evaluate whether, in a cohort of children presenting both with recurrent respiratory infections and with a history of exposure to tobacco smoke, these factors were related to a lower local production of interferon- (IFN-) when compared to a similar non-exposed population. The study group included 128 children undergoing adenoidectomy, presenting with more than three respiratory infections per year, independently of exposure to passive smoke at home. The intracellular cytokine profile of lymphocyte subsets in adenoids was evaluated by flow cytometry analysis. Children exposed to tobacco smoke suffered from a significantly greater number of respiratory infections and had a lower percentage of IFN - producing CD8+ cells in adenoids than non-exposed children, while other T-cell subsets were not affected. The effect of smoke exposure seems to be specific to the IFN - producing CD8+ cells in adenoids and may contribute to the increased susceptibility to the recurrence of respiratory infections.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalJournal of Interferon and Cytokine Research
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 1 2009
Externally publishedYes

Fingerprint

Adenoids
Smoke
Respiratory Tract Infections
Interferons
Tobacco
Adenoidectomy
Lymphocyte Subsets
T-Lymphocyte Subsets
Tobacco Products
Immune System
Flow Cytometry
Cytokines
Recurrence
Population

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

Cite this

Passive exposure to smoke results in defective interferon- production by adenoids in children with recurrent respiratory infections. / Marseglia, Gian Luigi; Avanzini, Maria Antonietta; Caimmi, Silvia; Caimmi, Davide; Marseglia, Alessia; Valsecchi, Chiara; Poddighe, Dimitri; Ciprandi, Giorgio; Pagella, Fabio; Klersy, Catherine; Castellazzi, Anna Maria.

In: Journal of Interferon and Cytokine Research, Vol. 29, No. 8, 01.08.2009, p. 427-431.

Research output: Contribution to journalArticle

Marseglia, GL, Avanzini, MA, Caimmi, S, Caimmi, D, Marseglia, A, Valsecchi, C, Poddighe, D, Ciprandi, G, Pagella, F, Klersy, C & Castellazzi, AM 2009, 'Passive exposure to smoke results in defective interferon- production by adenoids in children with recurrent respiratory infections', Journal of Interferon and Cytokine Research, vol. 29, no. 8, pp. 427-431. https://doi.org/10.1089/jir.2008.0108
Marseglia, Gian Luigi ; Avanzini, Maria Antonietta ; Caimmi, Silvia ; Caimmi, Davide ; Marseglia, Alessia ; Valsecchi, Chiara ; Poddighe, Dimitri ; Ciprandi, Giorgio ; Pagella, Fabio ; Klersy, Catherine ; Castellazzi, Anna Maria. / Passive exposure to smoke results in defective interferon- production by adenoids in children with recurrent respiratory infections. In: Journal of Interferon and Cytokine Research. 2009 ; Vol. 29, No. 8. pp. 427-431.
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