Pediatric End Stage Liver Diseases in Kazakhstan: the need for liver transplant development

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Abstract

The burden of pediatric liver diseases in our country and overall in most of developing countries is poorly studied and less reported. To estimate the number of pediatric end stage liver diseases (PELD) needed a curable transplant is hard to judge with an absence of reliable data. Also, Hepatoblastoma is among one of the common pediatric liver tumors that would need attention for considering liver transplant.
Aim. This analysis with a limited number of participants is intended to show the importance of developing liver transplant service in managing end stage pediatric liver diseases. Also, small data regarding Hepatoblastomas in pediatric liver diseases to demonstrate the implementation of liver transplant as a
treatment option in multifocal non-resectable Hepatoblastomas.
Material and methods. Retrospective analysis of data with pediatric liver transplant and Hepatoblastoma from UMC, National Research Center for Maternity and Child was analyzed. Considering the small number
of participants no statistical methods have been applied.
Results and discussion. The main indication for pediatric liver transplantation was biliary atresia with/without Kasai procedure prior to surgery. HLA typing within close family members is not necessary. Pediatric patients with unresectable Hepatoblastoma would benefit from referring to Transplant consideration on timely manner.
Conclusion. Liver transplantation is the only viable option for pediatric end stage liver diseases. The main etiology among pediatric cases in compliance with worldwide data is biliary atresia as our results presented. From this small analysis we aspire to advance our transplant service by considering liver transplantation in multifocal nonresectable hepatoblastoma cases. Nonetheless, HLA matching in close relatives has shown to be not necessary to focus in liver transplantation its role is important in further control of donor specific
antibodies in case of rejection occurrence.
Key words: pediatric liver diseases, liver transplantation, hepatoblastoma.
Original languageEnglish
Article numberUDC 616.36-089.87-053.2(574)
Pages (from-to)84 - 86
Number of pages3
JournalМеждународный профессиональный журнал «Медицина»
Publication statusPublished - Sep 30 2017
EventNazarbayev University Research Day -
Duration: Sep 7 2018 → …

Keywords

  • pediatric end stage liver diseases
  • pediatric hepatoblastoma
  • pediatric transplantation

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