Pediatric rhinosinusitis and asthma

Dimitri Poddighe, Ilaria Brambilla, Amelia Licari, Gian Luigi Marseglia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65% of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalRespiratory Medicine
Volume141
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Asthma
Pediatrics
Eosinophils
Comorbidity
Bone Marrow
Cytokines
Inflammation
Population

Keywords

  • Asthma
  • Basophil
  • Eosinophil
  • IL-5
  • Nasal polyposis
  • Rhinosinusitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Pediatric rhinosinusitis and asthma. / Poddighe, Dimitri; Brambilla, Ilaria; Licari, Amelia; Marseglia, Gian Luigi.

In: Respiratory Medicine, Vol. 141, 01.08.2018, p. 94-99.

Research output: Contribution to journalArticle

Poddighe, D, Brambilla, I, Licari, A & Marseglia, GL 2018, 'Pediatric rhinosinusitis and asthma', Respiratory Medicine, vol. 141, pp. 94-99. https://doi.org/10.1016/j.rmed.2018.06.016
Poddighe, Dimitri ; Brambilla, Ilaria ; Licari, Amelia ; Marseglia, Gian Luigi. / Pediatric rhinosinusitis and asthma. In: Respiratory Medicine. 2018 ; Vol. 141. pp. 94-99.
@article{e0692e28d103403ab1917e4f42b78a6d,
title = "Pediatric rhinosinusitis and asthma",
abstract = "Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65{\%} of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.",
keywords = "Asthma, Basophil, Eosinophil, IL-5, Nasal polyposis, Rhinosinusitis",
author = "Dimitri Poddighe and Ilaria Brambilla and Amelia Licari and Marseglia, {Gian Luigi}",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.rmed.2018.06.016",
language = "English",
volume = "141",
pages = "94--99",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Pediatric rhinosinusitis and asthma

AU - Poddighe, Dimitri

AU - Brambilla, Ilaria

AU - Licari, Amelia

AU - Marseglia, Gian Luigi

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65% of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.

AB - Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65% of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.

KW - Asthma

KW - Basophil

KW - Eosinophil

KW - IL-5

KW - Nasal polyposis

KW - Rhinosinusitis

UR - http://www.scopus.com/inward/record.url?scp=85049346096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049346096&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2018.06.016

DO - 10.1016/j.rmed.2018.06.016

M3 - Article

VL - 141

SP - 94

EP - 99

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

ER -