Abstract
Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65% of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 94-99 |
| Number of pages | 6 |
| Journal | Respiratory Medicine |
| Volume | 141 |
| DOIs | |
| Publication status | Published - Aug 1 2018 |
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Keywords
- Asthma
- Basophil
- Eosinophil
- IL-5
- Nasal polyposis
- Rhinosinusitis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Pediatric rhinosinusitis and asthma. / Poddighe, Dimitri; Brambilla, Ilaria; Licari, Amelia; Marseglia, Gian Luigi.
In: Respiratory Medicine, Vol. 141, 01.08.2018, p. 94-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pediatric rhinosinusitis and asthma
AU - Poddighe, Dimitri
AU - Brambilla, Ilaria
AU - Licari, Amelia
AU - Marseglia, Gian Luigi
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65% of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.
AB - Both asthma and rhinosinusitis are complex and heterogeneous diseases and, importantly, they often coexist: these diseases can be concomitant in 35–65% of affected children, according to different studies. Thus, evaluating this comorbidity in the clinical practice should be paramount. In this review, we focused our discussion on the multiple pathophysiological aspects that may link rhinosinusitis and asthma in the pediatric population. Although rhinosinusitis may exacerbate asthma through several mechanisms occurring by contiguity, actually this aspect seems to be only one component of the complex interplay between upper and lower airways. In particular, the onset of an important and persistent Th2-driven inflammatory process dominated by eosinophils presence at one site of the airways, may release into the bloodstream several cytokines; in their turn, those can lead to the stimulation of the bone marrow, which may function as a systemic amplifier of such an eosinophilic inflammation.
KW - Asthma
KW - Basophil
KW - Eosinophil
KW - IL-5
KW - Nasal polyposis
KW - Rhinosinusitis
UR - http://www.scopus.com/inward/record.url?scp=85049346096&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049346096&partnerID=8YFLogxK
U2 - 10.1016/j.rmed.2018.06.016
DO - 10.1016/j.rmed.2018.06.016
M3 - Article
VL - 141
SP - 94
EP - 99
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
ER -