PEG-Coated Superparamagnetic Dysprosium-Doped Fe3O4 Nanoparticles for Potential MRI Imaging

Timur Sh. Atabaev

doi:10.1007/s12668-017-0447-6

PEG-Coated Superparamagnetic Dysprosium-Doped Fe3O4 Nanoparticles for Potential MRI Imaging

Timur Sh. Atabaev

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.

Original language	English
Pages (from-to)	299-303
Number of pages	5
Journal	BioNanoScience
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/s12668-017-0447-6
Publication status	Published - 2018

Keywords

Superparamagnetic nanoparticles
MRI imaging
Fe3O4

ASJC Scopus subject areas

Materials Science(all)
Chemistry(all)
Chemical Engineering(all)

Access to Document

10.1007/s12668-017-0447-6

https://link.springer.com/article/10.1007/s12668-017-0447-6Licence: Other

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Cite this

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title = "PEG-Coated Superparamagnetic Dysprosium-Doped Fe3O4 Nanoparticles for Potential MRI Imaging",

abstract = "In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.",

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year = "2018",

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T1 - PEG-Coated Superparamagnetic Dysprosium-Doped Fe3O4 Nanoparticles for Potential MRI Imaging

AU - Atabaev, Timur Sh.

PY - 2018

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N2 - In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.

AB - In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.

KW - Superparamagnetic nanoparticles

KW - MRI imaging

KW - Fe3O4

U2 - 10.1007/s12668-017-0447-6

DO - 10.1007/s12668-017-0447-6

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