Abstract
In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.
Original language | English |
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Pages (from-to) | 299-303 |
Number of pages | 5 |
Journal | BioNanoScience |
Volume | 8 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- Superparamagnetic nanoparticles
- MRI imaging
- Fe3O4
ASJC Scopus subject areas
- General Materials Science
- General Chemistry
- General Chemical Engineering