PEG-Coated Superparamagnetic Dysprosium-Doped Fe3O4 Nanoparticles for Potential MRI Imaging

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10 Citations (Scopus)

Abstract

In recent years, superparamagnetic nanoparticles (NPs) have attracted considerable attention due to their high potential for biomedical applications. This study describes a facile preparation method of superparamagnetic polyethylene glycol (PEG)-coated dysprosium-doped Fe3O4 NPs for potential magnetic resonance imaging (MRI) applications. The structure, morphology, and magnetic properties of the dysprosium-doped Fe3O4 NPs were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and quantum design vibrating sample magnetometer (QD-VSM), respectively. The MRI imaging ability of the dysprosium-doped Fe3O4 NPs was assessed using a 1.5-T small animal MRI scanner. In addition, pilot studies were performed to examine the toxicity of the PEG-coated dysprosium-doped Fe3O4 NPs. The obtained results suggested that prepared NPs could be used for potential T2-weighted MRI imaging.
Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalBioNanoScience
Volume8
Issue number1
DOIs
Publication statusPublished - 2018

Keywords

  • Superparamagnetic nanoparticles
  • MRI imaging
  • Fe3O4

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemistry(all)
  • Chemical Engineering(all)

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