Perfluoroalkyl-functionalized hyperbranched polyglycerol as pore forming agents and supramolecular hosts in polymer microspheres

Olaf Wagner, Maximilian Zieringer, Wynter J. Duncanson, David A. Weitz, Rainer Haag

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction.

Original languageEnglish
Pages (from-to)20183-20194
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume16
Issue number9
DOIs
Publication statusPublished - Aug 26 2015
Externally publishedYes

Fingerprint

Microspheres
Polymers
porosity
Dendrimers
Porosity
polymers
Microbubbles
dendrimers
Microfluidics
Emulsions
Polymer matrix
Gases
Molecules
polyglycerol
emulsions
preparation
synthesis
matrices
gases
molecules

Keywords

  • Fluorous
  • Functional
  • Host-guest system
  • Microbubbles
  • Microfluidics
  • Non-covalent
  • Polyglycerol
  • Porous
  • Supramolecular
  • Template

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

Perfluoroalkyl-functionalized hyperbranched polyglycerol as pore forming agents and supramolecular hosts in polymer microspheres. / Wagner, Olaf; Zieringer, Maximilian; Duncanson, Wynter J.; Weitz, David A.; Haag, Rainer.

In: International Journal of Molecular Sciences, Vol. 16, No. 9, 26.08.2015, p. 20183-20194.

Research output: Contribution to journalArticle

Wagner, Olaf ; Zieringer, Maximilian ; Duncanson, Wynter J. ; Weitz, David A. ; Haag, Rainer. / Perfluoroalkyl-functionalized hyperbranched polyglycerol as pore forming agents and supramolecular hosts in polymer microspheres. In: International Journal of Molecular Sciences. 2015 ; Vol. 16, No. 9. pp. 20183-20194.
@article{bf1f92247ad6462c912f6527a06a6f80,
title = "Perfluoroalkyl-functionalized hyperbranched polyglycerol as pore forming agents and supramolecular hosts in polymer microspheres",
abstract = "Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12{\%} (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction.",
keywords = "Fluorous, Functional, Host-guest system, Microbubbles, Microfluidics, Non-covalent, Polyglycerol, Porous, Supramolecular, Template",
author = "Olaf Wagner and Maximilian Zieringer and Duncanson, {Wynter J.} and Weitz, {David A.} and Rainer Haag",
year = "2015",
month = "8",
day = "26",
doi = "10.3390/ijms160920183",
language = "English",
volume = "16",
pages = "20183--20194",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

TY - JOUR

T1 - Perfluoroalkyl-functionalized hyperbranched polyglycerol as pore forming agents and supramolecular hosts in polymer microspheres

AU - Wagner, Olaf

AU - Zieringer, Maximilian

AU - Duncanson, Wynter J.

AU - Weitz, David A.

AU - Haag, Rainer

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction.

AB - Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we optimized the process to a more convenient synthesis and higher porosities. The new hyperbranched polyglycerol porogens produced more pores and can be used to prepare microspheres with porosity up to 12% (v/v). The presented preparation forms pores with a perfluoroalkyl-functionalized surface that enables the resulting microspheres to act as supramolecular host systems. The microspheres can incorporate gases into the pores and actives in the polymer matrix, while the perfluoroalkylated pore surface can be used to immobilize perfluoro-tagged molecules onto the pores by fluorous-fluorous interaction.

KW - Fluorous

KW - Functional

KW - Host-guest system

KW - Microbubbles

KW - Microfluidics

KW - Non-covalent

KW - Polyglycerol

KW - Porous

KW - Supramolecular

KW - Template

UR - http://www.scopus.com/inward/record.url?scp=84940545247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940545247&partnerID=8YFLogxK

U2 - 10.3390/ijms160920183

DO - 10.3390/ijms160920183

M3 - Article

AN - SCOPUS:84940545247

VL - 16

SP - 20183

EP - 20194

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 9

ER -