Permeability of alginate microcapsules to secretory recombinant gene products

D. E. Awrey, M. Tse, G. Hortelano, P. L. Chang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Non-autologous somatic gene therapy is an alternate approach to delivering recombinant gene products through implantation of a 'universal' donor cell line engineered to produce a therapeutic gene product. The cells are immunologically isolated by enclosure in immunoprotective microcapsules fabricated from alginate-poly-L-lysine-alginate. The molecular weight cutoff of these microcapsules was thought to be

Original languageEnglish
Pages (from-to)472-484
Number of pages13
JournalBiotechnology and Bioengineering
Volume52
Issue number4
DOIs
Publication statusPublished - Nov 20 1996
Externally publishedYes

Fingerprint

Alginate
Capsules
Permeability
Genes
Gene therapy
Enclosures
Genetic Therapy
Molecular Weight
Molecular weight
Cells
Cell Line
alginic acid
alginate-polylysine-alginate
Therapeutics

Keywords

  • albumin
  • gene therapy
  • growth hormone
  • immunoglobulin
  • lysosomal enzymes

ASJC Scopus subject areas

  • Biotechnology
  • Microbiology

Cite this

Permeability of alginate microcapsules to secretory recombinant gene products. / Awrey, D. E.; Tse, M.; Hortelano, G.; Chang, P. L.

In: Biotechnology and Bioengineering, Vol. 52, No. 4, 20.11.1996, p. 472-484.

Research output: Contribution to journalArticle

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