Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor

Dan Liu, Iman El-Hariry, Anastasios J. Karayiannakis, Jonathan Wilding, Rebecca Chinery, Witold Kmiot, Pierre D. McCrea, William J. Gullick, Massimo Pignatelli

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Intestinal trefoil factor (TFF3) is a member of the trefoil family of peptides, which are constitutively expressed in the gastrointestinal tract. TFF3 has been shown to promote migration of intestinal epithelial cells in vitro and to enhance epithelial restitution in vivo. In the present study, we show that the stimulatory effect of TFF3 on the migration of HT29 colonic carcinoma cells requires the perturbation of E-cadherin function, a calcium- dependent cell-cell adhesion molecule in epithelia. A rapid (

Original languageEnglish
Pages (from-to)557-563
Number of pages7
JournalLaboratory Investigation
Volume77
Issue number6
Publication statusPublished - Dec 1997
Externally publishedYes

Fingerprint

Catenins
Epidermal Growth Factor Receptor
Phosphorylation
Cell Adhesion Molecules
Cadherins
Gastrointestinal Tract
Epithelium
Epithelial Cells
Calcium
Carcinoma
Trefoil Factor-3
Trefoil Factors
In Vitro Techniques

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Liu, D., El-Hariry, I., Karayiannakis, A. J., Wilding, J., Chinery, R., Kmiot, W., ... Pignatelli, M. (1997). Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor. Laboratory Investigation, 77(6), 557-563.

Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor. / Liu, Dan; El-Hariry, Iman; Karayiannakis, Anastasios J.; Wilding, Jonathan; Chinery, Rebecca; Kmiot, Witold; McCrea, Pierre D.; Gullick, William J.; Pignatelli, Massimo.

In: Laboratory Investigation, Vol. 77, No. 6, 12.1997, p. 557-563.

Research output: Contribution to journalArticle

Liu, D, El-Hariry, I, Karayiannakis, AJ, Wilding, J, Chinery, R, Kmiot, W, McCrea, PD, Gullick, WJ & Pignatelli, M 1997, 'Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor', Laboratory Investigation, vol. 77, no. 6, pp. 557-563.
Liu D, El-Hariry I, Karayiannakis AJ, Wilding J, Chinery R, Kmiot W et al. Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor. Laboratory Investigation. 1997 Dec;77(6):557-563.
Liu, Dan ; El-Hariry, Iman ; Karayiannakis, Anastasios J. ; Wilding, Jonathan ; Chinery, Rebecca ; Kmiot, Witold ; McCrea, Pierre D. ; Gullick, William J. ; Pignatelli, Massimo. / Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor. In: Laboratory Investigation. 1997 ; Vol. 77, No. 6. pp. 557-563.
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