Abstract
Intestinal trefoil factor (TFF3) is a member of the trefoil family of peptides, which are constitutively expressed in the gastrointestinal tract. TFF3 has been shown to promote migration of intestinal epithelial cells in vitro and to enhance epithelial restitution in vivo. In the present study, we show that the stimulatory effect of TFF3 on the migration of HT29 colonic carcinoma cells requires the perturbation of E-cadherin function, a calcium- dependent cell-cell adhesion molecule in epithelia. A rapid (
| Original language | English |
|---|---|
| Pages (from-to) | 557-563 |
| Number of pages | 7 |
| Journal | Laboratory Investigation |
| Volume | 77 |
| Issue number | 6 |
| Publication status | Published - Dec 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor. / Liu, Dan; El-Hariry, Iman; Karayiannakis, Anastasios J.; Wilding, Jonathan; Chinery, Rebecca; Kmiot, Witold; McCrea, Pierre D.; Gullick, William J.; Pignatelli, Massimo.
In: Laboratory Investigation, Vol. 77, No. 6, 12.1997, p. 557-563.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phosphorylation of β-Catenin and epidermal growth factor receptor by intestinal trefoil factor
AU - Liu, Dan
AU - El-Hariry, Iman
AU - Karayiannakis, Anastasios J.
AU - Wilding, Jonathan
AU - Chinery, Rebecca
AU - Kmiot, Witold
AU - McCrea, Pierre D.
AU - Gullick, William J.
AU - Pignatelli, Massimo
PY - 1997/12
Y1 - 1997/12
N2 - Intestinal trefoil factor (TFF3) is a member of the trefoil family of peptides, which are constitutively expressed in the gastrointestinal tract. TFF3 has been shown to promote migration of intestinal epithelial cells in vitro and to enhance epithelial restitution in vivo. In the present study, we show that the stimulatory effect of TFF3 on the migration of HT29 colonic carcinoma cells requires the perturbation of E-cadherin function, a calcium- dependent cell-cell adhesion molecule in epithelia. A rapid (
AB - Intestinal trefoil factor (TFF3) is a member of the trefoil family of peptides, which are constitutively expressed in the gastrointestinal tract. TFF3 has been shown to promote migration of intestinal epithelial cells in vitro and to enhance epithelial restitution in vivo. In the present study, we show that the stimulatory effect of TFF3 on the migration of HT29 colonic carcinoma cells requires the perturbation of E-cadherin function, a calcium- dependent cell-cell adhesion molecule in epithelia. A rapid (
UR - http://www.scopus.com/inward/record.url?scp=0031461322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031461322&partnerID=8YFLogxK
M3 - Article
VL - 77
SP - 557
EP - 563
JO - Laboratory Investigation
JF - Laboratory Investigation
SN - 0023-6837
IS - 6
ER -