Picomolar detection of thrombin with fiber-optic ball resonator sensor using optical backscatter reflectometry

Research output: Contribution to journalArticlepeer-review

Abstract

A ball resonator, positioned on the tip of an optical fiber, has been developed as a biosensor for the prototypic detection of thrombin. The device was fabricated with a fast and repeatable CO2 laser splicing method, followed by gold-sputtering and functionalization for the measurement of various protein concentrations. The ball resonator acts as a weak interferometer with a return loss below − 50 dB, and it is interrogated with an optical backscatter reflectometer measuring the reflection spectrum. We report here a sample presenting high sensitivity (1273.74 nm/RIU, RIU = refractive index units), which allows protein detection in the range 0.4–100 pM, with a limit of detection of 1.56 pM in logarithmic response.

Original languageEnglish
Article number166969
JournalOptik
Volume241
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Aptamer
  • Biosensor
  • Optical backscatter reflectometry
  • Optical ball resonator
  • Optical fiber biosensor
  • Thrombin

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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