Pim-1 kinase as cancer drug target

An update (Review)

Yernar Tursynbay, Jinfu Zhang, Zhi Li, Tursonjan Tokay, Zhaxybay Zhumadilov, Denglong Wu, Yingqiu Xie

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalBiomedical Reports
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Proto-Oncogene Proteins c-pim-1
Drug Resistance
Moloney murine leukemia virus
Information Services
Protein-Serine-Threonine Kinases
Epigenomics
Pharmaceutical Preparations
Immunotherapy
Neoplasms
Prostatic Neoplasms
Cell Survival
Cell Cycle
Protein Isoforms
Cells
Cell Membrane
Neoplasm Metastasis
Cell membranes
Viruses

Keywords

  • Drug target
  • Mitochondrial Pim1
  • Pim-1
  • Update

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pim-1 kinase as cancer drug target : An update (Review). / Tursynbay, Yernar; Zhang, Jinfu; Li, Zhi; Tokay, Tursonjan; Zhumadilov, Zhaxybay; Wu, Denglong; Xie, Yingqiu.

In: Biomedical Reports, Vol. 4, No. 2, 01.02.2016, p. 140-146.

Research output: Contribution to journalReview article

Tursynbay, Yernar ; Zhang, Jinfu ; Li, Zhi ; Tokay, Tursonjan ; Zhumadilov, Zhaxybay ; Wu, Denglong ; Xie, Yingqiu. / Pim-1 kinase as cancer drug target : An update (Review). In: Biomedical Reports. 2016 ; Vol. 4, No. 2. pp. 140-146.
@article{b25bd281b7154c3482d7b087d711a1a0,
title = "Pim-1 kinase as cancer drug target: An update (Review)",
abstract = "Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.",
keywords = "Drug target, Mitochondrial Pim1, Pim-1, Update",
author = "Yernar Tursynbay and Jinfu Zhang and Zhi Li and Tursonjan Tokay and Zhaxybay Zhumadilov and Denglong Wu and Yingqiu Xie",
year = "2016",
month = "2",
day = "1",
doi = "10.3892/br.2015.561",
language = "English",
volume = "4",
pages = "140--146",
journal = "Biomedical Reports",
issn = "2049-9434",
publisher = "Spandidos Publications",
number = "2",

}

TY - JOUR

T1 - Pim-1 kinase as cancer drug target

T2 - An update (Review)

AU - Tursynbay, Yernar

AU - Zhang, Jinfu

AU - Li, Zhi

AU - Tokay, Tursonjan

AU - Zhumadilov, Zhaxybay

AU - Wu, Denglong

AU - Xie, Yingqiu

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.

AB - Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.

KW - Drug target

KW - Mitochondrial Pim1

KW - Pim-1

KW - Update

UR - http://www.scopus.com/inward/record.url?scp=84962643784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962643784&partnerID=8YFLogxK

U2 - 10.3892/br.2015.561

DO - 10.3892/br.2015.561

M3 - Review article

VL - 4

SP - 140

EP - 146

JO - Biomedical Reports

JF - Biomedical Reports

SN - 2049-9434

IS - 2

ER -