Pim-1 kinase as cancer drug target: An update (Review)

Yernar Tursynbay, Jinfu Zhang, Zhi Li, Tursonjan Tokay, Zhaxybay Zhumadilov, Denglong Wu, Yingqiu Xie

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim-1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim-1 (Pim-1S and Pim-1L) show distinct cellular functions. Pim-1S predominately localizes to the nucleus and Pim-1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim-1 kinase and focus on its recent advances as a novel drug target.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalBiomedical Reports
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Drug target
  • Mitochondrial Pim1
  • Pim-1
  • Update

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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