Pipelle endometrial sampling success rates in Kazakhstani settings: results from a prospective cohort analysis

Milan Terzic, Gulzhanat Aimagambetova, Gauri Bapayeva, Talshyn Ukybassova, Kamila Kenbayeva, Aiym Kaiyrlykyzy, Bakytkali Ibrayimov, Alla Lyasova, Sanja Terzic, Ibrahim Alkatout, Georgios Gitas, İsmet Hortu, Simone Garzon, Antonio Simone Laganà

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The aim of this study was to evaluate the feasibility of Pipelle endometrial sampling and to explore factors influencing Pipelle success rate in the clinical settings of Kazakhstan. This prospective analysis included 87 patients who had undergone Pipelle biopsy due to medical indications for endometrial sampling. We analysed physician and patient-related factors potentially influencing the success rate of this method. Pipelle endometrial biopsy overall success rate was 82.76%. The indications for the procedure and patients’ age were key factors influencing Pipelle sampling success (p <.001). The success rate was the highest in the group with abnormal uterine bleeding as a biopsy indication in the reproductive age group (93.19%; p <.001). Pipelle biopsy was found to be an acceptable option for endometrial sampling in our clinical setting; at the same time, physicians should consider the potential influencing factors on its success rate like indications for the procedure, BMI and patients’ age as well as their menopausal status. In order to provide precise future directions, there is a need to study a larger number of patients.IMPACT STATEMENTWhat is already known on this subject? Compared to dilation and curettage sampling conducted in the operation room, Pipelle endometrial sampling is relatively inexpensive, associated with less morbidity, safe, accurate, and can be performed in an office setting. What do the results of this study add? This is the first prospective data analysis about Pipelle endometrial sampling in Kazakhstani population. What are the implications of these findings for clinical practice and/or further research? Enabling the timely diagnosis of current endometrial pathology, Pipelle endometrial sampling approach may have an important impact on healthcare safety and efficiency, and improve overall treatment outcomes and the quality of life of Kazakhstani population if used consistently.

Original languageEnglish
Pages (from-to)1255-1260
Number of pages6
JournalJournal of Obstetrics and Gynaecology
Issue number5
Publication statusPublished - 2022


  • Abnormal uterine bleeding
  • Pipelle biopsy
  • dilatation and curettage
  • endometrial hyperplasia
  • endometrial sampling

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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