Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa

Jörg Schreiber, Eva Riethmacher-Sonnenberg, Dieter Riethmacher, Elisabeth E. Tuerk, Janna Enderich, Michael R. Bösl, Michael Wegner

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

The GCM family of transcription factors consists of Drosophila melanogaster GCM, an important regulator of gliogenesis in the fly, and its two mammalian homologs, GCMa and GCMb. To clarify the function of these mammalian homologs, we deleted GCMa in mice. Genetic ablation of murine GCMa (mGCMa) is embryonic lethal, with mice dying between 9.5 and 10 days postcoitum. At the time of death, no abnormalities were apparent in the embryo proper. Nervous system development, in particular, was not impaired, as might have been expected in analogy to Drosophila GCM. Instead, placental failure was the cause of death. In agreement with the selective expression of mGCMa in labyrinthine trophoblasts, mutant placentas did not develop a functional labyrinth layer, which is necessary for nutrient and gas exchange between maternal and fetal blood. Only a few fetal blood vessels entered the placenta, and these failed to thrive and branch normally. Labyrinthine trophoblasts did not differentiate. All other layers of the placenta, including spongiotrophoblast and giant cell layer, formed normally. Our results indicate that mGCMa plays a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placenta.

Original languageEnglish
Pages (from-to)2466-2474
Number of pages9
JournalMolecular and Cellular Biology
Volume20
Issue number7
DOIs
Publication statusPublished - Apr 2000
Externally publishedYes

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Neuroglia
Placenta
Trophoblasts
Fetal Blood
Inner Ear
Giant Cells
Drosophila melanogaster
Diptera
Nervous System
Drosophila
Blood Vessels
Cause of Death
Signal Transduction
Transcription Factors
Embryonic Structures
Gases
Mothers
Food

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa. / Schreiber, Jörg; Riethmacher-Sonnenberg, Eva; Riethmacher, Dieter; Tuerk, Elisabeth E.; Enderich, Janna; Bösl, Michael R.; Wegner, Michael.

In: Molecular and Cellular Biology, Vol. 20, No. 7, 04.2000, p. 2466-2474.

Research output: Contribution to journalArticle

Schreiber, Jörg ; Riethmacher-Sonnenberg, Eva ; Riethmacher, Dieter ; Tuerk, Elisabeth E. ; Enderich, Janna ; Bösl, Michael R. ; Wegner, Michael. / Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa. In: Molecular and Cellular Biology. 2000 ; Vol. 20, No. 7. pp. 2466-2474.
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