Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation

Ilya Sotnikov, Tatyana Veremeyko, Sarah C. Starossom, Natalia Barteneva, Howard L. Weiner, Eugene D. Ponomarev

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Platelets respond to vascular damage and contribute to inflammation, but their role in the neurodegenerative diseases is unknown. We found that the systemic administration of brain lipid rafts induced a massive platelet activation and degranulation resulting in a life-threatening anaphylactic-like response in mice. Platelets were engaged by the sialated glycosphingolipids (gangliosides) integrated in the rigid structures of astroglial and neuronal lipid rafts. The brain-abundant gangliosides GT1b and GQ1b were specifically recognized by the platelets and this recognition involved multiple receptors with P-selectin (CD62P) playing the central role. During the neuroinflammation, platelets accumulated in the central nervous system parenchyma, acquired an activated phenotype and secreted proinflammatory factors, thereby triggering immune response cascades. This study determines a new role of platelets which directly recognize a neuronal damage and communicate with the cells of the immune system in the pathogenesis of neurodegenerative diseases.

Original languageEnglish
Article numbere58979
JournalPLoS One
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 26 2013
Externally publishedYes

Fingerprint

gangliosides
glycolipids
Glycolipids
neurodegenerative diseases
Platelets
Brain
Blood Platelets
glycosphingolipids
brain
platelet activation
lipids
blood vessels
Neurodegenerative diseases
central nervous system
immune system
pathogenesis
inflammation
Neurodegenerative Diseases
immune response
phenotype

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation. / Sotnikov, Ilya; Veremeyko, Tatyana; Starossom, Sarah C.; Barteneva, Natalia; Weiner, Howard L.; Ponomarev, Eugene D.

In: PLoS One, Vol. 8, No. 3, e58979, 26.03.2013.

Research output: Contribution to journalArticle

Sotnikov, Ilya ; Veremeyko, Tatyana ; Starossom, Sarah C. ; Barteneva, Natalia ; Weiner, Howard L. ; Ponomarev, Eugene D. / Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation. In: PLoS One. 2013 ; Vol. 8, No. 3.
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