Poly-l-arginine based materials as instructive substrates for fibroblast synthesis of collagen

Hannah C. Bygd, Dana Akilbekova, Adam Muñoz, Kiva D. Forsmark, Kaitlin M. Bratlie

Research output: Contribution to journalArticle

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Abstract

The interactions of cells and surrounding tissues with biomaterials used in tissue engineering, wound healing, and artificial organs ultimately determine their fate in vivo. We have demonstrated the ability to tune fibroblast responses with the use of varied material chemistries. In particular, we examined cell morphology, cytokine production, and collagen fiber deposition angles in response to a library of arginine-based polymeric materials. The data presented here shows a large range of vascular endothelial growth factor (VEGF) secretion (0.637 ng/106 cells/day to 3.25 ng/106

LanguageEnglish
Pages47-57
Number of pages11
JournalBiomaterials
Volume63
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

Arginine
Fibroblasts
Collagen
Biocompatible Materials
Tissue engineering
Biomaterials
Vascular Endothelial Growth Factor A
Substrates
Tissue Engineering
Wound Healing
Artificial organs
Fibers
Artificial Organs
Cell Communication
Tissue
Cytokines
Cell Movement
Polymers
Intercellular Signaling Peptides and Proteins

Keywords

  • Cell morphology
  • Collagen
  • Collagen structure
  • Fibroblast

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Bygd, H. C., Akilbekova, D., Muñoz, A., Forsmark, K. D., & Bratlie, K. M. (2015). Poly-l-arginine based materials as instructive substrates for fibroblast synthesis of collagen. Biomaterials, 63, 47-57. DOI: 10.1016/j.biomaterials.2015.05.045

Poly-l-arginine based materials as instructive substrates for fibroblast synthesis of collagen. / Bygd, Hannah C.; Akilbekova, Dana; Muñoz, Adam; Forsmark, Kiva D.; Bratlie, Kaitlin M.

In: Biomaterials, Vol. 63, 01.09.2015, p. 47-57.

Research output: Contribution to journalArticle

Bygd, HC, Akilbekova, D, Muñoz, A, Forsmark, KD & Bratlie, KM 2015, 'Poly-l-arginine based materials as instructive substrates for fibroblast synthesis of collagen' Biomaterials, vol. 63, pp. 47-57. DOI: 10.1016/j.biomaterials.2015.05.045
Bygd HC, Akilbekova D, Muñoz A, Forsmark KD, Bratlie KM. Poly-l-arginine based materials as instructive substrates for fibroblast synthesis of collagen. Biomaterials. 2015 Sep 1;63:47-57. Available from, DOI: 10.1016/j.biomaterials.2015.05.045
Bygd, Hannah C. ; Akilbekova, Dana ; Muñoz, Adam ; Forsmark, Kiva D. ; Bratlie, Kaitlin M./ Poly-l-arginine based materials as instructive substrates for fibroblast synthesis of collagen. In: Biomaterials. 2015 ; Vol. 63. pp. 47-57
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