Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review

Li Xinming, Cui Yingde, Andrew W. Lloyd, Sergey V. Mikhalovsky, Susan R. Sandeman, Carol A. Howel, Liao Liewen

Research output: Contribution to journalReview article

173 Citations (Scopus)

Abstract

Only about 5% of drugs administrated by eye drops are bioavailable, and currently eye drops account for more than 90% of all ophthalmic formulations. The bioavailability of ophthalmic drugs can be improved by a soft contact lens-based ophthalmic drug delivery system. Several polymeric hydrogels have been investigated for soft contact lens-based ophthalmic drug delivery systems: (i) polymeric hydrogels for conventional contact lens to absorb and release ophthalmic drugs; (ii) polymeric hydrogels for piggyback contact lens combining with a drug plate or drug solution; (iii) surface-modified polymeric hydrogels to immobilize drugs on the surface of contact lenses; (iv) polymeric hydrogels for inclusion of drugs in a colloidal structure dispersed in the lens; (v) ion ligand-containing polymeric hydrogels; (vi) molecularly imprinted polymeric hydrogels which provide the contact lens with a high affinity and selectivity for a given drug. Polymeric hydrogels for these contact lens-based ophthalmic drug delivery systems, their advantages and drawbacks are critically analyzed in this review.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalContact Lens and Anterior Eye
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 1 2008

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Keywords

  • Contact lens
  • Hydrogels
  • Ophthalmic drug delivery system

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

Cite this

Xinming, L., Yingde, C., Lloyd, A. W., Mikhalovsky, S. V., Sandeman, S. R., Howel, C. A., & Liewen, L. (2008). Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review. Contact Lens and Anterior Eye, 31(2), 57-64. https://doi.org/10.1016/j.clae.2007.09.002