TY - JOUR
T1 - Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems
T2 - A review
AU - Xinming, Li
AU - Yingde, Cui
AU - Lloyd, Andrew W.
AU - Mikhalovsky, Sergey V.
AU - Sandeman, Susan R.
AU - Howel, Carol A.
AU - Liewen, Liao
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Only about 5% of drugs administrated by eye drops are bioavailable, and currently eye drops account for more than 90% of all ophthalmic formulations. The bioavailability of ophthalmic drugs can be improved by a soft contact lens-based ophthalmic drug delivery system. Several polymeric hydrogels have been investigated for soft contact lens-based ophthalmic drug delivery systems: (i) polymeric hydrogels for conventional contact lens to absorb and release ophthalmic drugs; (ii) polymeric hydrogels for piggyback contact lens combining with a drug plate or drug solution; (iii) surface-modified polymeric hydrogels to immobilize drugs on the surface of contact lenses; (iv) polymeric hydrogels for inclusion of drugs in a colloidal structure dispersed in the lens; (v) ion ligand-containing polymeric hydrogels; (vi) molecularly imprinted polymeric hydrogels which provide the contact lens with a high affinity and selectivity for a given drug. Polymeric hydrogels for these contact lens-based ophthalmic drug delivery systems, their advantages and drawbacks are critically analyzed in this review.
AB - Only about 5% of drugs administrated by eye drops are bioavailable, and currently eye drops account for more than 90% of all ophthalmic formulations. The bioavailability of ophthalmic drugs can be improved by a soft contact lens-based ophthalmic drug delivery system. Several polymeric hydrogels have been investigated for soft contact lens-based ophthalmic drug delivery systems: (i) polymeric hydrogels for conventional contact lens to absorb and release ophthalmic drugs; (ii) polymeric hydrogels for piggyback contact lens combining with a drug plate or drug solution; (iii) surface-modified polymeric hydrogels to immobilize drugs on the surface of contact lenses; (iv) polymeric hydrogels for inclusion of drugs in a colloidal structure dispersed in the lens; (v) ion ligand-containing polymeric hydrogels; (vi) molecularly imprinted polymeric hydrogels which provide the contact lens with a high affinity and selectivity for a given drug. Polymeric hydrogels for these contact lens-based ophthalmic drug delivery systems, their advantages and drawbacks are critically analyzed in this review.
KW - Contact lens
KW - Hydrogels
KW - Ophthalmic drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=41949139148&partnerID=8YFLogxK
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U2 - 10.1016/j.clae.2007.09.002
DO - 10.1016/j.clae.2007.09.002
M3 - Review article
C2 - 17962066
AN - SCOPUS:41949139148
VL - 31
SP - 57
EP - 64
JO - Contact Lens and Anterior Eye
JF - Contact Lens and Anterior Eye
SN - 1367-0484
IS - 2
ER -