Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in inhabitants of astana, the capital city of Kazakhstan

Alexandr B. Kuranov, Mikhail N. Vavilov, Gulshara Zh Abildinova, Ainur R. Akilzhanova, Aisha N. Iskakova, Elena V. Zholdybayeva, Margarita N. Boldyreva, Claudia A. Müller, Kuvat T. Momynaliev, João Pinto

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Abstract

Methodology/Principal Findings: A total of 157 unrelated Kazakh ethnic individuals from Astana were genotyped using sequence based typing (SBTMethod) for HLA-DRB1, -DQA1 and -DQB1 loci. Allele frequencies, neighborjoining method, and multidimensional scaling analysis have been obtained for comparison with other world populations. Statistical analyses were performed using Arlequin v3.11. Applying the software PAST v. 2.17 the resulting genetic distance matrix was used for a multidimensional scaling analysis (MDS). Respectively 37, 17 and 19 alleles were observed at HLA-DRB1, -DQA1 and -DQB1 loci. The most frequent alleles were HLA-DRB1∗07:01 (13.1%), HLA-DQA1∗03:01 (13.1%) and HLA-DQB1∗03:01 (17.6%). In the observed group of Kazakhs DRB1∗07:01- DQA1∗02:01-DQB1∗02:01 (8.0%) was the most common three loci haplotype. DRB1∗10:01-DQB1∗05:01 showed the strongest linkage disequilibrium. The Kazakh population shows genetic kinship with the Kazakhs from China, Uyghurs, Mongolians, Todzhinians, Tuvinians and as well as with other Siberians and Asians.

Conclusions/Significance: The HLA-DRB1, -DQA1and -DQB1 loci are highly polymorphic in the Kazakh population, and this population has the closest relationship with other Asian and Siberian populations.

Background: Kazakhstan has been inhabited by different populations, such as the Kazakh, Kyrgyz, Uzbek and others. Here we investigate allelic and haplotypic polymorphisms of human leukocyte antigen (HLA) genes at DRB1, DQA1 and DQB1 loci in the Kazakh ethnic group, and their genetic relationship between world populations.

Original languageEnglish
Article numbere115265
JournalPLoS ONE
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 22 2014

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Kuranov, A. B., Vavilov, M. N., Abildinova, G. Z., Akilzhanova, A. R., Iskakova, A. N., Zholdybayeva, E. V., Boldyreva, M. N., Müller, C. A., Momynaliev, K. T., & Pinto, J. (2014). Polymorphisms of HLA-DRB1, -DQA1 and -DQB1 in inhabitants of astana, the capital city of Kazakhstan. PLoS ONE, 9(12), [e115265]. https://doi.org/10.1371/journal.pone.0115265