Vozmozhnyǐ mekhanizm obrazovaniia ATF v énergopreobrazuiushchikh biologicheskikh membranakh.

Translated title of the contribution: Possible mechanism of ATP formation in energy-transforming biological membranes

L. A. Bliumenfel'd, A. N. Tikhonov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An "elementary act" of ATP formation from ADP and Pi in energy-transducing organels (mitochondria, chloroplasts and chromatophores) can be realized without closed membrane vesicles, pieces of membranes and F0-component of H+ATPase. The "elementary act" is initiated by a rather fast deprotonation of several acid groups of the coupling factor F1 (or CF1), this process leads to structurally non-equilibrium state of the enzyme due to the appearance of "additional" negative charges in unchanged protein globula. The endergonic step of ATP synthesis, i. e. release of tightly-bound ATP into the aqueous medium, occurs during conformational relaxation of the non-equilibrium state of H+ATPase. Closed membrane vesicles are necessary for a cyclic return of the enzyme to the initial state with protonized functional groups, this provides multiple synthesis of ATP under the steady state and quasi-stationary conditions. The energetical aspects and details of possible schemes of ATP synthesis initiated by artificial electrochemical gradient of protons, as well as ATP formation during oxidative and photophosphorylation are discussed here.

Original languageRussian
Pages (from-to)800-813
Number of pages14
JournalBiofizika
Volume32
Issue number5
Publication statusPublished - Sep 1987
Externally publishedYes

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Adenosine Triphosphate
Membranes
Proton-Translocating ATPases
Photophosphorylation
Chromatophores
Enzymes
Chloroplasts
Adenosine Diphosphate
Protons
Mitochondria
Acids
Proteins

ASJC Scopus subject areas

  • Biophysics

Cite this

Vozmozhnyǐ mekhanizm obrazovaniia ATF v énergopreobrazuiushchikh biologicheskikh membranakh. / Bliumenfel'd, L. A.; Tikhonov, A. N.

In: Biofizika, Vol. 32, No. 5, 09.1987, p. 800-813.

Research output: Contribution to journalArticle

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