Postnatal cytomegalovirus infection in an infant with congenital thrombocytopenia

How it can support or mislead the diagnosis of Wiskott-Aldrich syndrome

Dimitri Poddighe, Elena Virginia Comi, Marco Nedbal, Annarosa Soresina, Paola Bruni

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A male newborn developed a post-natal cytomegalovirus (CMV) infection, arising in the clinical setting of congenital thrombocytopenia, which was diagnosed as being alloimmune. The evidence of active CMV infection in an infant showing slow-resolution lower airways infection, persistent neonatal and low platelet volume thrombocytopenia, and diffuse eczema (associated to very high levels of serum immunoglobulin E) led to the diagnosis of Wiskott-Aldrich syndrome (WAS) before the third month of life, despite the presence of several confounding clinical factors. The correct interpretation of all clinical features supported the precocious diagnosis of WAS.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalInfezioni in Medicina
Volume24
Issue number3
Publication statusPublished - Jan 1 2016
Externally publishedYes

Fingerprint

Wiskott-Aldrich Syndrome
Cytomegalovirus Infections
Thrombocytopenia
Eczema
Immunoglobulin E
Blood Platelets
Newborn Infant
Infection
Serum

Keywords

  • Cytomegalovirus
  • Thrombocytopenia
  • Wiskott-Aldrich syndrome

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Postnatal cytomegalovirus infection in an infant with congenital thrombocytopenia : How it can support or mislead the diagnosis of Wiskott-Aldrich syndrome. / Poddighe, Dimitri; Comi, Elena Virginia; Nedbal, Marco; Soresina, Annarosa; Bruni, Paola.

In: Infezioni in Medicina, Vol. 24, No. 3, 01.01.2016, p. 237-240.

Research output: Contribution to journalArticle

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