Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support

R. Garrett Jeffries, Yerbol Mussin, Denis S. Bulanin, Laura W. Lund, Ergin Kocyildirim, Zhaksybay Zh Zhumadilov, Farkhad S. Olzhayev, William J. Federspiel, Peter D. Wearden

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim. The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood fl ow rates, applied in pediatrics.Material and methods. The bench testing of the device with pediatric catheters has been performed. The bovine blood and carboxymethylcellulose water solution were used as a model. The device operation data, blood gas analysis and hydrodynamic pressure data were collected. Results.The pump curve results show that at the maximum rotation rate the Hemolung device was able to achieve blood fl ow rates substantially greater than targeted 280 ml/min that is used in pediatrics. The calculated operating curve plotted against the observed pressure-fl ow relationships shows that the device could be able to operate against pressure heads of 80 and 100 mm Hg. In general, carbon dioxide elimination rate increased along with increase of the rotation rate, reaching maximum levels of 168 ± 0.3 ml CO2/min at 1750 RPM and a blood fl ow rate of 670 ± 42 ml/min. As a passive oxygenator, the small gas exchange fi ber surface area of the Hemolung resulted in oxygen saturations of 81% and 78% at 1.5 and 2.0 L/min, respectively.Conclusion. The results of this study show the prospect of application of the Hemolung system in pediatrics.

Original languageEnglish
Pages (from-to)888-899
Number of pages12
JournalInternational Journal of Artificial Organs
Volume37
Issue number12
DOIs
Publication statusPublished - 2014

Fingerprint

Pediatrics
Carbon Dioxide
Carbon dioxide
Blood
Equipment and Supplies
Catheters
Pressure
Blood gas analysis
Gases
Oxygenators
Carboxymethylcellulose Sodium
Blood Gas Analysis
Hydrodynamics
Pumps
Oxygen
Water
Testing

Keywords

  • Extracorporeal carbon dioxide removal (ECCO<inf>2</inf>R)
  • Gas exchange
  • Hemolung
  • In vitro characterization
  • Pediatric extracorporeal membrane oxygenation (ECMO)
  • Pump-oxygenator

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support. / Jeffries, R. Garrett; Mussin, Yerbol; Bulanin, Denis S.; Lund, Laura W.; Kocyildirim, Ergin; Zhumadilov, Zhaksybay Zh; Olzhayev, Farkhad S.; Federspiel, William J.; Wearden, Peter D.

In: International Journal of Artificial Organs, Vol. 37, No. 12, 2014, p. 888-899.

Research output: Contribution to journalArticle

Jeffries, R. Garrett ; Mussin, Yerbol ; Bulanin, Denis S. ; Lund, Laura W. ; Kocyildirim, Ergin ; Zhumadilov, Zhaksybay Zh ; Olzhayev, Farkhad S. ; Federspiel, William J. ; Wearden, Peter D. / Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system with active mixing for pediatric respiratory support. In: International Journal of Artificial Organs. 2014 ; Vol. 37, No. 12. pp. 888-899.
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AB - Aim. The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood fl ow rates, applied in pediatrics.Material and methods. The bench testing of the device with pediatric catheters has been performed. The bovine blood and carboxymethylcellulose water solution were used as a model. The device operation data, blood gas analysis and hydrodynamic pressure data were collected. Results.The pump curve results show that at the maximum rotation rate the Hemolung device was able to achieve blood fl ow rates substantially greater than targeted 280 ml/min that is used in pediatrics. The calculated operating curve plotted against the observed pressure-fl ow relationships shows that the device could be able to operate against pressure heads of 80 and 100 mm Hg. In general, carbon dioxide elimination rate increased along with increase of the rotation rate, reaching maximum levels of 168 ± 0.3 ml CO2/min at 1750 RPM and a blood fl ow rate of 670 ± 42 ml/min. As a passive oxygenator, the small gas exchange fi ber surface area of the Hemolung resulted in oxygen saturations of 81% and 78% at 1.5 and 2.0 L/min, respectively.Conclusion. The results of this study show the prospect of application of the Hemolung system in pediatrics.

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