Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response

Arman Saparov, Vyacheslav Ogay, Talgat Nurgozhin, Medet Jumabay, William C W Chen

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) have attracted the attention of researchers and clinicians for their ability to differentiate into a number of cell types, participate in tissue regeneration, and repair the damaged tissues by producing various growth factors and cytokines, as well as their unique immunoprivilege in alloreactive hosts. The immunomodulatory functions of exogenous MSCs have been widely investigated in immune-mediated inflammatory diseases and transplantation research. However, a harsh environment at the site of tissue injury/inflammation with insufficient oxygen supply, abundance of reactive oxygen species, and presence of other harmful molecules that damage the adoptively transferred cells collectively lead to low survival and engraftment of the transferred cells. Preconditioning of MSCs ex vivo by hypoxia, inflammatory stimulus, or other factors/conditions prior to their use in therapy is an adaptive strategy that prepares MSCs to survive in the harsh environment and to enhance their regulatory function of the local immune responses. This review focuses on a number of approaches in preconditioning human MSCs with the goal of augmenting their capacity to regulate both innate and adaptive immune responses.

Original languageEnglish
Pages (from-to)3924858
JournalStem Cells International
Volume2016
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Review
  • Journal Article

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