PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse

Menaka Rajapakse, Guang Lan Zhang, Kellathur N. Srinivasan, Bertil Schmidt, Nikolai Petrovsky, Vladimir Brusic

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The non-obese diabetic (NOD) mouse is a widely used animal model for study of autoimmune diseases, in particular human type 1 diabetes mellitus (T1DM). Identification of the subset of peptides that bind MHC molecules comprising the H-2g7 haplotype of NOD mouse and thereby representing potential NOD T-cell epitopes is important for research into the pathogenesis and immunotherapy of T1DM. The H-2g7 haplotype comprises the MHC class-I molecules Kd and Db and a single class-II molecule I-Ag7. We have developed a prediction system, PREDNOD, for accurate identification of peptides that bind the MHC molecules constituting the H-2g7 haplotype. PREDNOD is accessible at http://antigen.i2r.a-star.edu.sg/Ag7.

Original languageEnglish
Pages (from-to)645-650
Number of pages6
JournalAutoimmunity
Volume39
Issue number8
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Fingerprint

Inbred NOD Mouse
Haplotypes
Type 1 Diabetes Mellitus
Peptides
T-Lymphocyte Epitopes
Immunotherapy
Autoimmune Diseases
Animal Models
Antigens
Research

Keywords

  • Autoimmune diabetes
  • I-A haplotype
  • NOD
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Rajapakse, M., Zhang, G. L., Srinivasan, K. N., Schmidt, B., Petrovsky, N., & Brusic, V. (2006). PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse. Autoimmunity, 39(8), 645-650. https://doi.org/10.1080/08916930601062494

PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse. / Rajapakse, Menaka; Zhang, Guang Lan; Srinivasan, Kellathur N.; Schmidt, Bertil; Petrovsky, Nikolai; Brusic, Vladimir.

In: Autoimmunity, Vol. 39, No. 8, 12.2006, p. 645-650.

Research output: Contribution to journalArticle

Rajapakse, M, Zhang, GL, Srinivasan, KN, Schmidt, B, Petrovsky, N & Brusic, V 2006, 'PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse', Autoimmunity, vol. 39, no. 8, pp. 645-650. https://doi.org/10.1080/08916930601062494
Rajapakse, Menaka ; Zhang, Guang Lan ; Srinivasan, Kellathur N. ; Schmidt, Bertil ; Petrovsky, Nikolai ; Brusic, Vladimir. / PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse. In: Autoimmunity. 2006 ; Vol. 39, No. 8. pp. 645-650.
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