Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain

Yann Humeau, Hamdy Shaban, Stephanie Bissière, Andreas Lüthi

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

The induction of associative synaptic plasticity in the mammalian central nervous system classically depends on coincident presynaptic and postsynaptic activity. According to this principle, associative homosynaptic long-term potentiation (LTP) of excitatory synaptic transmission can be induced only if synaptic release occurs during postsynaptic depolarization. In contrast, heterosynaptic plasticity in mammals is considered to rely on activity-independent, non-associative processes. Here we describe a novel mechanism underlying the induction of associative LTP in the lateral amygdala (LA). Simultaneous activation of converging cortical and thalamic afferents specifically induced associative, N-methyl-D-aspartate (NMDA) -receptor-dependent LTP at cortical, but not at thalamic, inputs. Surprisingly, the induction of associative LTP at cortical inputs was completely independent of postsynaptic activity, including depolarization, postsynaptic NMDA receptor activation or an increase in post-synaptic Ca2+ concentration, and did not require network activity. LTP expression was mediated by a persistent increase in the presynaptic probability of release at cortical afferents. Our study shows the presynaptic induction and expression of heterosynaptic and associative synaptic plasticity on simultaneous activity of converging afferents. Our data indicate that input specificity of associative LTP can be determined exclusively by presynaptic properties.

Original languageEnglish
Pages (from-to)841-845
Number of pages5
JournalNature
Volume426
Issue number6968
DOIs
Publication statusPublished - Dec 18 2003
Externally publishedYes

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Long-Term Potentiation
Brain
Neuronal Plasticity
N-Methyl-D-Aspartate Receptors
Amygdala
Synaptic Transmission
Mammals
Central Nervous System

ASJC Scopus subject areas

  • General

Cite this

Humeau, Y., Shaban, H., Bissière, S., & Lüthi, A. (2003). Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain. Nature, 426(6968), 841-845. https://doi.org/10.1038/nature02194

Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain. / Humeau, Yann; Shaban, Hamdy; Bissière, Stephanie; Lüthi, Andreas.

In: Nature, Vol. 426, No. 6968, 18.12.2003, p. 841-845.

Research output: Contribution to journalArticle

Humeau, Y, Shaban, H, Bissière, S & Lüthi, A 2003, 'Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain', Nature, vol. 426, no. 6968, pp. 841-845. https://doi.org/10.1038/nature02194
Humeau, Yann ; Shaban, Hamdy ; Bissière, Stephanie ; Lüthi, Andreas. / Presynaptic induction of heterosynaptic associative plasticity in the mammalian brain. In: Nature. 2003 ; Vol. 426, No. 6968. pp. 841-845.
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