Proliferating cell nuclear antigen in benign breast diseases

M. R. Cardillo, G. W.H. Stamp, M. Pignatelli

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The expression of PCNA was examined by immunohistochemistry on 95 formalin-fixed breast surgical specimens. Seventy-four were benign breast disease, 3 atypical hyperplasia; 5 in situ carcinoma; 13 invasive carcinoma. Forty-two percent of benign breast disease, 75% of atypical hyperplasia/in situ carcinoma and 92% of invasive breast carcinoma expressed PCNA nuclear staining. Forty percent of cysts, 15.78% of sclerosing adenosis, 22.22% of adenosis, and 17.19% of epitheliosis expressed low cyclin protein levels (PCNA score I, < 18%); 20% of cysts, 31.57% of sclerosing adenosis, 5.55% of adenosis and 43.47% of epitheliosis expressed moderate levels (PCNA score II, 18 to 50%); whereas 50% of atypical hyperplasia/in situ carcinoma and 54% of invasive breast carcinoma contained high levels (PCNA score III, > 50%). This study on PCNA/cyclin localization suggests that PCNA is an early indicator of ongoing cellular proliferation.

Original languageEnglish
Pages (from-to)476-481
Number of pages6
JournalEuropean Journal of Gynaecological Oncology
Issue number6
Publication statusPublished - Jan 1 1995


  • Benign breast diseases
  • Immunohistochemistry
  • Proliferating cell nuclear antigen (PCNA)

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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