Proliferatsiia kletok selezenki v otvet na Bordetella pertussis.

Translated title of the contribution: Proliferation of spleen cells in response to Bordetella pertussis

V. V. Khorobrykh, N. S. Barteneva, A. E. Snegireva, A. V. Pronin, O. S. Merimskaia

Research output: Contribution to journalArticlepeer-review


Vaccine strain 305 of B. pertussis in a dose of 10(8)-10(11) cells was shown to be mitogenic for splenocytes of BALB/c mice and nude mice. When added in a dose of 10(10) B. pertussis exerted a more pronounced mitogenic effect than phytohemagglutinin P, which was less powerful, however, than that of Con A, B. pertussis caused a greater stimulation of DNA synthesis in lymphocytes than B mitogens whose action depended on the differentiation stages of B lymphocytes. This is likely to hint towards a possible action of B. pertussis on immature B cells and/or their precursors. The cells of T lineage (T1 cells and/or T precursors) can also be involved.

Translated title of the contributionProliferation of spleen cells in response to Bordetella pertussis
Original languageRussian
Pages (from-to)112-114
Number of pages3
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Issue number7
Publication statusPublished - Jul 1 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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