Proliferatsiia kletok selezenki v otvet na Bordetella pertussis.

Translated title of the contribution: Proliferation of spleen cells in response to Bordetella pertussis

V. V. Khorobrykh, N. S. Barteneva, A. E. Snegireva, A. V. Pronin, O. S. Merimskaia

Research output: Contribution to journalArticle

Abstract

Vaccine strain 305 of B. pertussis in a dose of 10(8)-10(11) cells was shown to be mitogenic for splenocytes of BALB/c mice and nude mice. When added in a dose of 10(10) B. pertussis exerted a more pronounced mitogenic effect than phytohemagglutinin P, which was less powerful, however, than that of Con A, B. pertussis caused a greater stimulation of DNA synthesis in lymphocytes than B mitogens whose action depended on the differentiation stages of B lymphocytes. This is likely to hint towards a possible action of B. pertussis on immature B cells and/or their precursors. The cells of T lineage (T1 cells and/or T precursors) can also be involved.

Original languageRussian
Pages (from-to)112-114
Number of pages3
JournalByulleten Eksperimentalnoi Biologii i Meditsiny
Volume96
Issue number7
Publication statusPublished - Jul 1983
Externally publishedYes

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Bordetella pertussis
Lymphocytes
Spleen
Cell Proliferation
Mitogens
Vaccines
Cells
T-Lymphoid Precursor Cells
B-Lymphoid Precursor Cells
DNA
Cell Lineage
Nude Mice
B-Lymphocytes
phytohemagglutinin-P

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Khorobrykh, V. V., Barteneva, N. S., Snegireva, A. E., Pronin, A. V., & Merimskaia, O. S. (1983). Proliferatsiia kletok selezenki v otvet na Bordetella pertussis. Byulleten Eksperimentalnoi Biologii i Meditsiny, 96(7), 112-114.

Proliferatsiia kletok selezenki v otvet na Bordetella pertussis. / Khorobrykh, V. V.; Barteneva, N. S.; Snegireva, A. E.; Pronin, A. V.; Merimskaia, O. S.

In: Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 96, No. 7, 07.1983, p. 112-114.

Research output: Contribution to journalArticle

Khorobrykh, VV, Barteneva, NS, Snegireva, AE, Pronin, AV & Merimskaia, OS 1983, 'Proliferatsiia kletok selezenki v otvet na Bordetella pertussis.', Byulleten Eksperimentalnoi Biologii i Meditsiny, vol. 96, no. 7, pp. 112-114.
Khorobrykh, V. V. ; Barteneva, N. S. ; Snegireva, A. E. ; Pronin, A. V. ; Merimskaia, O. S. / Proliferatsiia kletok selezenki v otvet na Bordetella pertussis. In: Byulleten Eksperimentalnoi Biologii i Meditsiny. 1983 ; Vol. 96, No. 7. pp. 112-114.
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