Vaccine strain 305 of B. pertussis in a dose of 10(8)-10(11) cells was shown to be mitogenic for splenocytes of BALB/c mice and nude mice. When added in a dose of 10(10) B. pertussis exerted a more pronounced mitogenic effect than phytohemagglutinin P, which was less powerful, however, than that of Con A, B. pertussis caused a greater stimulation of DNA synthesis in lymphocytes than B mitogens whose action depended on the differentiation stages of B lymphocytes. This is likely to hint towards a possible action of B. pertussis on immature B cells and/or their precursors. The cells of T lineage (T1 cells and/or T precursors) can also be involved.
|Translated title of the contribution||Proliferation of spleen cells in response to Bordetella pertussis|
|Number of pages||3|
|Journal||Byulleten Eksperimentalnoi Biologii i Meditsiny|
|Publication status||Published - Jul 1 1983|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)