Prolonged, but transient, elevation of liver and biliary function tests in a healthy infant affected with breast milk jaundice

Dimitri Poddighe, Lucia Castelli, Gian Luigi Marseglia, Paola Bruni

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Unconjugated hyperbilirubinaemia is a common finding in newborns. When it is exaggerated, it is usually investigated in order to exclude several diseases, such as newborn' s haemolytic diseases, infections or hypothyroidism. Breast milk jaundice is a form of neonatal jaundice related to breast feeding and it is not usually associated with any clinical issue and/or other laboratory abnormalities. We describe a case of breast milk jaundice being associated, unexpectedly, to significant elevation of plasmatic liver and biliary enzymes. Despite the infant's good clinical condition and growth, several investigations were performed and these ruled out metabolic, infectious and autoimmune liver diseases. All liver function tests normalised by 6-7 months of life. We suggest that the finding of hypertransaminasaemia and hyper-γ-glutamyl transpeptidase in a benign clinical context (similar to what we described) should be followed for 6-7 months before performing sophisticated and expensive diagnostic investigations which aim at excluding some unlikely and severe diseases in a completely asymptomatic infant.

Original languageEnglish
JournalBMJ Case Reports
DOIs
Publication statusPublished - May 28 2014
Externally publishedYes

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Liver Function Tests
Human Milk
Jaundice
Neonatal Jaundice
Fetal Erythroblastosis
Hyperbilirubinemia
gamma-Glutamyltransferase
Hypothyroidism
Breast Feeding
Autoimmune Diseases
Liver Diseases
Newborn Infant
Liver
Enzymes
Growth
Infection

ASJC Scopus subject areas

  • Medicine(all)

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Prolonged, but transient, elevation of liver and biliary function tests in a healthy infant affected with breast milk jaundice. / Poddighe, Dimitri; Castelli, Lucia; Marseglia, Gian Luigi; Bruni, Paola.

In: BMJ Case Reports, 28.05.2014.

Research output: Contribution to journalArticle

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