Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification

Yishan Zheng, Nicholas Pescatore, Yury Gogotsi, Boris Dyatkin, Ganesh Ingavle, Vadym Mochalin, Tochukwu Ozulumba, Sergey Mikhalovsky, Susan Sandeman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sepsis is a complex clinical syndrome that features excessive release of cytokines and other inflammatory mediators that could lead to organ dysfunction. Despite different treatment and management options, sepsis associated high morbidity and mortality rates remain. This has prompted intensive research into alternative therapeutic approaches such as targeted removal of sepsis related molecules using extracorporeal hemoperfusion. In this study, we explore the use of graphene nanoplatelets (GNP) as low-cost alternative hemosorbents for rapid removal of a broad spectrum of proinflammatory cytokine markers. Firstly, the physical characteristics, cytotoxicity, and cytokine marker adsorption profile of GNP were assessed. The results not only confirmed the surface characteristics of GNP and their ability to rapidly remove cytokine markers, but also indicated a low cytotoxicity towards the hepatic cell line HepG2. GNP were then incorporated into a freestanding flexible GNP-poly(tetrafluoroethylene) film with preserved surface characteristics and cytokine adsorption profile for potential use in hemoperfusion applications.

Original languageEnglish
Article number6274072
JournalJournal of Nanomaterials
Volume2018
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Detoxification
Graphite
Graphene
Cytokines
Adsorption
Composite materials
Cytotoxicity
Polytetrafluoroethylenes
Molecules
Costs

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Zheng, Y., Pescatore, N., Gogotsi, Y., Dyatkin, B., Ingavle, G., Mochalin, V., ... Sandeman, S. (2018). Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. Journal of Nanomaterials, 2018, [6274072]. https://doi.org/10.1155/2018/6274072

Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. / Zheng, Yishan; Pescatore, Nicholas; Gogotsi, Yury; Dyatkin, Boris; Ingavle, Ganesh; Mochalin, Vadym; Ozulumba, Tochukwu; Mikhalovsky, Sergey; Sandeman, Susan.

In: Journal of Nanomaterials, Vol. 2018, 6274072, 01.01.2018.

Research output: Contribution to journalArticle

Zheng, Y, Pescatore, N, Gogotsi, Y, Dyatkin, B, Ingavle, G, Mochalin, V, Ozulumba, T, Mikhalovsky, S & Sandeman, S 2018, 'Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification', Journal of Nanomaterials, vol. 2018, 6274072. https://doi.org/10.1155/2018/6274072
Zheng, Yishan ; Pescatore, Nicholas ; Gogotsi, Yury ; Dyatkin, Boris ; Ingavle, Ganesh ; Mochalin, Vadym ; Ozulumba, Tochukwu ; Mikhalovsky, Sergey ; Sandeman, Susan. / Rapid Adsorption of Proinflammatory Cytokines by Graphene Nanoplatelets and Their Composites for Extracorporeal Detoxification. In: Journal of Nanomaterials. 2018 ; Vol. 2018.
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