The feasibility of a reactive distillation process for producing glycerol ethers by etherification of glycerol with iso-butene catalyzed by heterogeneous acid catalysts, e.g., Amberlist 35, was demonstrated. The process was performed in a reactive distillation column with few un-reactive trays placed above and below the reactive zone. Glycerol was fed as liquid at the top of the reactive zone. Iso-butene entered in the column as a vapor stream at the bottom. The bottom product contained the di- and tri-ethers of glycerol (main products). The vapor outlet stream contained the mono-ether and the excess of iso-butene, which were separated in a decanter. The mono-ether was returned as reflux, while the excess of iso-butene was recycled. The design was performed using AspenPlus. This is an abstract of a paper presented at the 2011 AIChE Spring Meeting & 7th Global Congress on Process Safety (Chicago, IL 3/13-17/2011).