Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture

Cristina A de Frutos, Guy Bouvier, Yoko Arai, Morgane S Thion, Ludmilla Lokmane, Maryama Keita, Mario Garcia-Dominguez, Patrick Charnay, Tatsumi Hirata, Dieter Riethmacher, Elizabeth A Grove, Fadel Tissir, Mariano Casado, Alessandra Pierani, Sonia Garel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The neocortex undergoes extensive developmental growth, but how its architecture adapts to expansion remains largely unknown. Here, we investigated how early born Cajal-Retzius (CR) neurons, which regulate the assembly of cortical circuits, maintain a dense superficial distribution in the growing neocortex. We found that CR cell density is sustained by an activity-dependent importation of olfactory CR cells, which migrate into the neocortex after they have acted as axonal guidepost cells in the olfactory system. Furthermore, using mouse genetics, we showed that CR cell density severely affects the architecture of layer 1, a key site of input integration for neocortical networks, leading to an excitation/inhibition ratio imbalance. Our study reveals that neurons reenter migration several days after their initial positioning, thereby performing sequential developmental roles in olfactory cortex and neocortex. This atypical process is essential to regulate CR cell density during growth, which in turn ensures the correct wiring of neocortical circuitry. VIDEO ABSTRACT.

Original languageEnglish
Pages (from-to)435-448
Number of pages14
JournalNeuron
Volume92
Issue number2
DOIs
Publication statusPublished - Oct 19 2016
Externally publishedYes

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    de Frutos, C. A., Bouvier, G., Arai, Y., Thion, M. S., Lokmane, L., Keita, M., Garcia-Dominguez, M., Charnay, P., Hirata, T., Riethmacher, D., Grove, E. A., Tissir, F., Casado, M., Pierani, A., & Garel, S. (2016). Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture. Neuron, 92(2), 435-448. https://doi.org/10.1016/j.neuron.2016.09.020