TY - JOUR
T1 - Recapping the Features of SARS-CoV-2 and Its Main Variants
T2 - Status and Future Paths
AU - Ortega, Miguel A.
AU - García-Montero, Cielo
AU - Fraile-Martinez, Oscar
AU - Colet, Paolo
AU - Baizhaxynova, Ardak
AU - Mukhtarova, Kymbat
AU - Alvarez-Mon, Melchor
AU - Kanatova, Kaznagul
AU - Asúnsolo, Angel
AU - Sarría-Santamera, Antonio
N1 - Funding Information:
This research was funded by NU 280720FD1901 and NU 021220CRP0822, and co-financed FirstCMRe-funded as part of the UnionClinicalresponseManifes-to the pandemicImmuneofEva-COVID-19.Vaccination co-Referen-by the European Development Regional Fund “A way to achieve Europe” (ERDF) B2020/MITICAD-Mutations in the Spike Protein of porttations sion cerns ces.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6
Y1 - 2022/6
N2 - Over the two years that we have been experiencing the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic, our challenges have been the race to develop vaccines and the difficulties in fighting against new variants due to the rapid ability of the virus to evolve. In this sense, different organizations have identified and classified the different variants that have been emerging, distinguishing between variants of concern (VOC), variants of interest (VOI), or variants under monitoring (VUM). The following review aims to describe the latest updates focusing on VOC and already de-escalated variants, as well as to describe the impact these have had on the global situation. Understanding the intrinsic properties of SARS-CoV-2 and its interaction with the immune system and vaccination is essential to make out the underlying mechanisms that have led to the appearance of these variants, helping to determine the next steps for better public management of this pandemic.
AB - Over the two years that we have been experiencing the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic, our challenges have been the race to develop vaccines and the difficulties in fighting against new variants due to the rapid ability of the virus to evolve. In this sense, different organizations have identified and classified the different variants that have been emerging, distinguishing between variants of concern (VOC), variants of interest (VOI), or variants under monitoring (VUM). The following review aims to describe the latest updates focusing on VOC and already de-escalated variants, as well as to describe the impact these have had on the global situation. Understanding the intrinsic properties of SARS-CoV-2 and its interaction with the immune system and vaccination is essential to make out the underlying mechanisms that have led to the appearance of these variants, helping to determine the next steps for better public management of this pandemic.
KW - COVID-19
KW - de-escalation
KW - epidemiology
KW - SARS-CoV-2
KW - variants
KW - VOC
KW - VOI
UR - http://www.scopus.com/inward/record.url?scp=85135470441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135470441&partnerID=8YFLogxK
U2 - 10.3390/jpm12060995
DO - 10.3390/jpm12060995
M3 - Review article
C2 - 35743779
SN - 2075-4426
VL - 12
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 6
M1 - 995
ER -
