Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex i mouse mutants

Johannes Mayer, Gesine Reichart, Tursonjan Tokay, Falko Lange, Simone Baltrusch, Christian Junghanss, Olaf Wolkenhauer, Robert Jaster, Manfred Kunz, Markus Tiedge, Saleh Ibrahim, Georg Fuellen, Rüdiger Köhling

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are known to negatively impact on life span and can result in apoptosis and tissue loss in, e.g., skeletal muscle or reduce learning abilities. The functional impact of homoplasmic specific mtDNA point mutations, e.g., in genes coding for the electron transport chain, however, remains a matter of debate. The present study contributes to this discussion and provides evidence that a single point mutation in complex I of the respiratory chain is associated with impairment of spatial navigation in adolescent (6-month-old) mice, i.e., reduced performance in the Morris Water Maze, which goes along with increased production of reactive oxygen species (ROS) in juvenile mice (3 months) but not at the age of phenotype expression. A point mutation in complex III goes along with only a mild and non-significant negative effect on cognitive performance and no significant changes in ROS production. These findings suggest to also consider the ontogenetic development of phenotypes when studying mtDNA mutations and highlights a possible impact of complex I dysfunction on the emergence of neurological deficits.

Original languageEnglish
Article numbere123863
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 8 2015

Fingerprint

Mitochondrial DNA
Superoxides
superoxide anion
mitochondrial DNA
point mutation
learning
Point Mutation
NADH dehydrogenase (ubiquinone)
mutants
mice
electron transport chain
Electron Transport
reactive oxygen species
Reactive Oxygen Species
Phenotype
mutation
phenotype
Mutation
Aptitude
Electron Transport Complex III

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex i mouse mutants. / Mayer, Johannes; Reichart, Gesine; Tokay, Tursonjan; Lange, Falko; Baltrusch, Simone; Junghanss, Christian; Wolkenhauer, Olaf; Jaster, Robert; Kunz, Manfred; Tiedge, Markus; Ibrahim, Saleh; Fuellen, Georg; Köhling, Rüdiger.

In: PLoS One, Vol. 10, No. 4, e123863, 08.04.2015.

Research output: Contribution to journalArticle

Mayer, J, Reichart, G, Tokay, T, Lange, F, Baltrusch, S, Junghanss, C, Wolkenhauer, O, Jaster, R, Kunz, M, Tiedge, M, Ibrahim, S, Fuellen, G & Köhling, R 2015, 'Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex i mouse mutants', PLoS One, vol. 10, no. 4, e123863. https://doi.org/10.1371/journal.pone.0123863
Mayer, Johannes ; Reichart, Gesine ; Tokay, Tursonjan ; Lange, Falko ; Baltrusch, Simone ; Junghanss, Christian ; Wolkenhauer, Olaf ; Jaster, Robert ; Kunz, Manfred ; Tiedge, Markus ; Ibrahim, Saleh ; Fuellen, Georg ; Köhling, Rüdiger. / Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex i mouse mutants. In: PLoS One. 2015 ; Vol. 10, No. 4.
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