Movement and transportation of fine particles in formations leads to clogging the pores and reduction in permeability. This type of formation damage is stronglycontingent upon water salinity and ionic conditions in the formation. The main parameters which control the particle release are the interactions and forces between particles and porous medium surfaces. Changing salinity which leads to pH alteration, affects these interactions and subsequently the fine migration process. Hence, pH and salinity variations should be considered to study and evaluate the portion of fine migration in formation damage. The principal challenge in this research therefore, is to try to change the surface potential of the porous mediums by injecting MgO nanoparticles intothem and to establish the most effective concentration of nanofluid that can give the best results in making fines fixed into the pores. We studied the effects of this treatment on fine detachment in different pH and salinity conditions. A homogeneous core structure which is composed ofglass beads and fines represents the porous media in our experiments. The surface of pores was soaked with MgO nanoparticles. To evaluate the effectiveness of MgO Nano particles, we determined PZC1 and CSC2for both Nano fluid soaked medium and reference case. We also modified the salinity and pH conditions requiredto minimize the fine migrationintensity. Our results illustrate that the magnitude of the repulsion forces in compare with the attractions between fines and wall surfaces, was considerably diminished when the surface of glass beads was soaked by MgO nanoparticle. An increase of PZC from 2 to 9.3 was also a quantitative evidence of striking improvement effect of these nanoparticles.