Regressing atypical histiocytosis, a regressing cutaneous phase of Ki-1- positive anaplastic large cell lymphoma

Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion

R. J. Motley, B. Jasani, A. M. Ford, C. H. Poynton, J. E. Calonje-Daly, P. J A Holt

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.

Original languageEnglish
Pages (from-to)476-483
Number of pages8
JournalCancer
Volume70
Issue number2
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Histiocytosis
Anaplastic Large-Cell Lymphoma
Cytogenetics
Nucleic Acids
Immunophenotyping
Skin
Lymphoma
T-Cell Receptor Genes
Cell Lineage
Chromosomes
T-Lymphocytes
Neoplasms

Keywords

  • anaplastic large cell lymphoma
  • Ki-1 lymphoma
  • regressing atypical histiocytosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Regressing atypical histiocytosis, a regressing cutaneous phase of Ki-1- positive anaplastic large cell lymphoma : Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion. / Motley, R. J.; Jasani, B.; Ford, A. M.; Poynton, C. H.; Calonje-Daly, J. E.; Holt, P. J A.

In: Cancer, Vol. 70, No. 2, 1992, p. 476-483.

Research output: Contribution to journalArticle

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abstract = "Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.",
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