Abstract
Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.
| Original language | English |
|---|---|
| Pages (from-to) | 476-483 |
| Number of pages | 8 |
| Journal | Cancer |
| Volume | 70 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1992 |
| Externally published | Yes |
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Keywords
- anaplastic large cell lymphoma
- Ki-1 lymphoma
- regressing atypical histiocytosis
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Regressing atypical histiocytosis, a regressing cutaneous phase of Ki-1- positive anaplastic large cell lymphoma : Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion. / Motley, R. J.; Jasani, B.; Ford, A. M.; Poynton, C. H.; Calonje-Daly, J. E.; Holt, P. J A.
In: Cancer, Vol. 70, No. 2, 1992, p. 476-483.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regressing atypical histiocytosis, a regressing cutaneous phase of Ki-1- positive anaplastic large cell lymphoma
T2 - Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion
AU - Motley, R. J.
AU - Jasani, B.
AU - Ford, A. M.
AU - Poynton, C. H.
AU - Calonje-Daly, J. E.
AU - Holt, P. J A
PY - 1992
Y1 - 1992
N2 - Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.
AB - Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.
KW - anaplastic large cell lymphoma
KW - Ki-1 lymphoma
KW - regressing atypical histiocytosis
UR - http://www.scopus.com/inward/record.url?scp=0026728493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026728493&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(19920715)70:2<476::AID-CNCR2820700216>3.0.CO;2-5
DO - 10.1002/1097-0142(19920715)70:2<476::AID-CNCR2820700216>3.0.CO;2-5
M3 - Article
VL - 70
SP - 476
EP - 483
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 2
ER -