Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self‐remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T‐cell lineage, although T‐cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki‐1‐positive anaplastic large cell lymphoma of the skin. Cancer 1992; 70:476–483.
|Number of pages||8|
|Publication status||Published - Jul 15 1992|
- Ki‐1 lymphoma
- anaplastic large cell lymphoma
- regressing atypical histiocytosis
ASJC Scopus subject areas
- Cancer Research