Regressing atypical histiocytosis, a regressing cutaneous phase of ki‐i‐positive anaplastic large cell lymphoma. Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion

R. J. Motley, B. Jasani, A. M. Ford, C. H. Poynton, J. E. Calonje‐Daly, P. J.A. Holt

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Background. Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self‐remitting, the condition may progress to systemic lymphoma. Methods. Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies. Results. Immunophenotyping studies indicated the condition was of T‐cell lineage, although T‐cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma. Conclusions. The authors believe regressing atypical histiocytosis is a regressing phase of Ki‐1‐positive anaplastic large cell lymphoma of the skin. Cancer 1992; 70:476–483.

Original languageEnglish
Pages (from-to)476-483
Number of pages8
Issue number2
Publication statusPublished - Jul 15 1992



  • Ki‐1 lymphoma
  • anaplastic large cell lymphoma
  • regressing atypical histiocytosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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