Regulation of mhc i molecules in glioblastoma cells and the sensitizing of nk cells

Timo Burster, Fabian Gärtner, Christiane Bulach, Anuar Zhanapiya, Adrian Gihring, Uwe Knippschild

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be by-passed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) molecules. Natural killer (NK) cells can eliminate tumor cells in a MHC I antigen presentation‐independent manner by an array of activating and inhibitory receptors, which are promising candidates for immunotherapy. Here we summarize the latest findings in recogniz-ing and regulating MHC I molecules that affect NK cell surveillance of glioblastoma cells.

Original languageEnglish
Article number236
JournalPharmaceuticals
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Cathepsin G
  • Immunotherapy
  • MHC
  • NK cells
  • Proteases

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Regulation of mhc i molecules in glioblastoma cells and the sensitizing of nk cells'. Together they form a unique fingerprint.

Cite this