Abstract
OBJECTIVE: Vascular calcification is commonly seen in patients with end-stage renal disease (ESRD). Fetuin-A has been found to be a vascular calcification inhibitor and its level is significantly low in ESRD patients. The aim of our study was to investigate the relation between coronary artery calcification, inflammation and fetuin-A levels in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL and METHODS: 46 PD (M/F=28/18) and 34 (M/F=20/14) HD patients were included in the study. Coronary artery calcification scoring was made by multi slice computed tomography. PD and HD patients were divided into 2 groups according to their median CACS values Serum levels of fetuin-A, CRP, IL-6 and TNF-a are studied. RESULTS: There were no differences in demographic features of PD and HD patients. There was a correlation between CACS, advanced age, dialysis vintage and fetuin-A. We could not find any correlation between infiammatory markers and CACS. There was a statistically significant difference between fetuin-A and CACS groups. CONCLUSION: Age, duration of dialysis, fetuin-A levels were found to be related to CACS in PD and HD patients. Fetuin-A may play a role in increased mortality in this population via facilitating CACS.
| Original language | English |
|---|---|
| Pages (from-to) | 111-117 |
| Number of pages | 7 |
| Journal | Turkish Nephrology, Dialysis and Transplantation Journal |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 5 2012 |
| Externally published | Yes |
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Keywords
- Fetuin-A
- Hemodialysis
- Inflammation
- Peritoneal dialysis
- Vascular calcification
ASJC Scopus subject areas
- Surgery
- Urology
Cite this
Relationship between fetuin-A, inflammation, coronary artery calcification in hemodialysis and peritoneal dialysis patients. / Türkmen, Kültigin; Kayikçioǧlu, Hatice; Özbek, Orhan; Gaipov, Abduzhappar; Yerlikaya, Fatma Hümeyra; Toker, Aysun; Tonbul, Halil Zeki.
In: Turkish Nephrology, Dialysis and Transplantation Journal, Vol. 21, No. 2, 05.07.2012, p. 111-117.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between fetuin-A, inflammation, coronary artery calcification in hemodialysis and peritoneal dialysis patients
AU - Türkmen, Kültigin
AU - Kayikçioǧlu, Hatice
AU - Özbek, Orhan
AU - Gaipov, Abduzhappar
AU - Yerlikaya, Fatma Hümeyra
AU - Toker, Aysun
AU - Tonbul, Halil Zeki
PY - 2012/7/5
Y1 - 2012/7/5
N2 - OBJECTIVE: Vascular calcification is commonly seen in patients with end-stage renal disease (ESRD). Fetuin-A has been found to be a vascular calcification inhibitor and its level is significantly low in ESRD patients. The aim of our study was to investigate the relation between coronary artery calcification, inflammation and fetuin-A levels in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL and METHODS: 46 PD (M/F=28/18) and 34 (M/F=20/14) HD patients were included in the study. Coronary artery calcification scoring was made by multi slice computed tomography. PD and HD patients were divided into 2 groups according to their median CACS values Serum levels of fetuin-A, CRP, IL-6 and TNF-a are studied. RESULTS: There were no differences in demographic features of PD and HD patients. There was a correlation between CACS, advanced age, dialysis vintage and fetuin-A. We could not find any correlation between infiammatory markers and CACS. There was a statistically significant difference between fetuin-A and CACS groups. CONCLUSION: Age, duration of dialysis, fetuin-A levels were found to be related to CACS in PD and HD patients. Fetuin-A may play a role in increased mortality in this population via facilitating CACS.
AB - OBJECTIVE: Vascular calcification is commonly seen in patients with end-stage renal disease (ESRD). Fetuin-A has been found to be a vascular calcification inhibitor and its level is significantly low in ESRD patients. The aim of our study was to investigate the relation between coronary artery calcification, inflammation and fetuin-A levels in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL and METHODS: 46 PD (M/F=28/18) and 34 (M/F=20/14) HD patients were included in the study. Coronary artery calcification scoring was made by multi slice computed tomography. PD and HD patients were divided into 2 groups according to their median CACS values Serum levels of fetuin-A, CRP, IL-6 and TNF-a are studied. RESULTS: There were no differences in demographic features of PD and HD patients. There was a correlation between CACS, advanced age, dialysis vintage and fetuin-A. We could not find any correlation between infiammatory markers and CACS. There was a statistically significant difference between fetuin-A and CACS groups. CONCLUSION: Age, duration of dialysis, fetuin-A levels were found to be related to CACS in PD and HD patients. Fetuin-A may play a role in increased mortality in this population via facilitating CACS.
KW - Fetuin-A
KW - Hemodialysis
KW - Inflammation
KW - Peritoneal dialysis
KW - Vascular calcification
UR - http://www.scopus.com/inward/record.url?scp=84863214498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863214498&partnerID=8YFLogxK
U2 - 10.5262/tndt.2012.1002.02
DO - 10.5262/tndt.2012.1002.02
M3 - Article
VL - 21
SP - 111
EP - 117
JO - Turkish Nephrology, Dialysis and Transplantation Journal
JF - Turkish Nephrology, Dialysis and Transplantation Journal
SN - 1300-7718
IS - 2
ER -