Relationship between fetuin-A, inflammation, coronary artery calcification in hemodialysis and peritoneal dialysis patients

Kültigin Türkmen, Hatice Kayikçioǧlu, Orhan Özbek, Abduzhappar Gaipov, Fatma Hümeyra Yerlikaya, Aysun Toker, Halil Zeki Tonbul

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVE: Vascular calcification is commonly seen in patients with end-stage renal disease (ESRD). Fetuin-A has been found to be a vascular calcification inhibitor and its level is significantly low in ESRD patients. The aim of our study was to investigate the relation between coronary artery calcification, inflammation and fetuin-A levels in peritoneal dialysis (PD) and hemodialysis (HD) patients. MATERIAL and METHODS: 46 PD (M/F=28/18) and 34 (M/F=20/14) HD patients were included in the study. Coronary artery calcification scoring was made by multi slice computed tomography. PD and HD patients were divided into 2 groups according to their median CACS values Serum levels of fetuin-A, CRP, IL-6 and TNF-a are studied. RESULTS: There were no differences in demographic features of PD and HD patients. There was a correlation between CACS, advanced age, dialysis vintage and fetuin-A. We could not find any correlation between infiammatory markers and CACS. There was a statistically significant difference between fetuin-A and CACS groups. CONCLUSION: Age, duration of dialysis, fetuin-A levels were found to be related to CACS in PD and HD patients. Fetuin-A may play a role in increased mortality in this population via facilitating CACS.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalTurkish Nephrology, Dialysis and Transplantation Journal
Volume21
Issue number2
DOIs
Publication statusPublished - Jul 5 2012
Externally publishedYes

Keywords

  • Fetuin-A
  • Hemodialysis
  • Inflammation
  • Peritoneal dialysis
  • Vascular calcification

ASJC Scopus subject areas

  • Surgery
  • Urology

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