Relationship of HLA protein display to activation of 2-5A synthetase in HBe antigen or anti-HBe positive chronic HBV infection

T. Ikeda, M. Pignatelli, A. M L Lever, H. C. Thomas

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In this study we have examined the density of HLA class I protein display on the hepatocytes of patients with HBe antigen (HBeAg) or anti-HBe (HBeAb) positive chronic hepatitis B virus (HBV) infection and related this to the level of interferon activation of these cells determined by measuring hepatic oligo 2-5A synthetase activity. In HBeAg positive patients the density of HLA class I (HLA-I) protein was not significantly increased above that found in uninfected liver, but levels of 2-5A synthetase were twice normal. In anti-HBe positive patients, HLA-I density was markedly increased in the presence of normal 2-5A synthetase activity. These data are consistent with type I (α or β) interferon activation of the hepatocytes in HBeAg positive patients and type II (γ) interferon activity in anti-HBe positive subjects.

Original languageEnglish
Pages (from-to)1498-1501
Number of pages4
JournalGut
Volume27
Issue number12
Publication statusPublished - 1986
Externally publishedYes

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2',5'-Oligoadenylate Synthetase
Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Antigens
Hepatocytes
Proteins
Interferon Type I
Liver
Interferons
Interferon-gamma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Relationship of HLA protein display to activation of 2-5A synthetase in HBe antigen or anti-HBe positive chronic HBV infection. / Ikeda, T.; Pignatelli, M.; Lever, A. M L; Thomas, H. C.

In: Gut, Vol. 27, No. 12, 1986, p. 1498-1501.

Research output: Contribution to journalArticle

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