Relationships between the effects of redox potential, α-Thenoyltrifluoroacetone and malonate on O2- and H2O2 generation by submitochondrial particles in the presence of succinate and antimycin

Marina Ksenzenko; Alexander A. Konstantinov; Gennadiy B. Khomutov; Alexander N. Tikhonov; E. K. Ruuge

doi:10.1016/0014-5793(84)80579-7

Relationships between the effects of redox potential, α-Thenoyltrifluoroacetone and malonate on O₂^- and H₂O₂ generation by submitochondrial particles in the presence of succinate and antimycin

Marina Ksenzenko, Alexander A. Konstantinov, Gennadiy B. Khomutov, Alexander N. Tikhonov, E. K. Ruuge

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The rate of the antimycin-induced H₂O₂ and O₂^XXXgeneration in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of $ ̃1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at E_h, values more positive than the optimal. The modulation of O₂^xxx and H₂O₂ generation by these inhibitors can be explained by their effects on the steady-state redox potential(s) of the component(s) of mitochondrial site 2.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	FEBS Letters
Volume	175
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(84)80579-7
Publication status	Published - Sep 17 1984
Externally published	Yes

Keywords

Q-cycle
Redox titration
Respiratory
Superoxide
Ubisemiquinone
chain
generation
α-thenoyltrifluoroacetone

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Relationships between the effects of redox potential, α-Thenoyltrifluoroacetone and malonate on O₂^- and H₂O₂ generation by submitochondrial particles in the presence of succinate and antimycin. / Ksenzenko, Marina; Konstantinov, Alexander A.; Khomutov, Gennadiy B.; Tikhonov, Alexander N.; Ruuge, E. K.

In: FEBS Letters, Vol. 175, No. 1, 17.09.1984, p. 105-108.

Research output: Contribution to journal › Article › peer-review

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abstract = "The rate of the antimycin-induced H2O2 and O2XXXgeneration in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of ${\~ }1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at Eh, values more positive than the optimal. The modulation of O2xxx and H2O2 generation by these inhibitors can be explained by their effects on the steady-state redox potential(s) of the component(s) of mitochondrial site 2.",

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AU - Konstantinov, Alexander A.

AU - Khomutov, Gennadiy B.

AU - Tikhonov, Alexander N.

AU - Ruuge, E. K.

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