Relationships between the effects of redox potential, α-Thenoyltrifluoroacetone and malonate on O2- and H2O2 generation by submitochondrial particles in the presence of succinate and antimycin

Marina Ksenzenko, Alexander A. Konstantinov, Gennadiy B. Khomutov, Alexander N. Tikhonov, E. K. Ruuge

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The rate of the antimycin-induced H2O2 and O2XXXgeneration in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of $ ̃1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at Eh, values more positive than the optimal. The modulation of O2xxx and H2O2 generation by these inhibitors can be explained by their effects on the steady-state redox potential(s) of the component(s) of mitochondrial site 2.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalFEBS Letters
Volume175
Issue number1
DOIs
Publication statusPublished - Sep 17 1984
Externally publishedYes

Keywords

  • Q-cycle
  • Redox titration
  • Respiratory
  • Superoxide
  • Ubisemiquinone
  • chain
  • generation
  • α-thenoyltrifluoroacetone

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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