Abstract
The rate of the antimycin-induced H2O2 and O2XXXgeneration in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of $ ̃1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at Eh, values more positive than the optimal. The modulation of O2xxx and H2O2 generation by these inhibitors can be explained by their effects on the steady-state redox potential(s) of the component(s) of mitochondrial site 2.
Original language | English |
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Pages (from-to) | 105-108 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 175 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sep 17 1984 |
Externally published | Yes |
Keywords
- Q-cycle
- Redox titration
- Respiratory
- Superoxide
- Ubisemiquinone
- chain
- generation
- α-thenoyltrifluoroacetone
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology