The global problem of increasing cases of antibiotic resistance in patients with acne is mainly determined by the regional prescription practices and patient compliance with doctor's directions and genomic variability of Propionibacterium acnes. The research was aimed at analyzing the causal profile and risk factors for development of resistant forms of acne. Crosssectional study of the causal profile was conducted and risk factors for development of resistant forms of acne were studied on the basis of dermatological clinics of the city in Kazan, Republic of Tatarstan, among 983 patients with acne of both genders aged 18 to 41 years. Bacteria were isolated using the bacteriological method, sensitivity to antibiotics was determined by the Kirby-Bauer disk diffusion test, the risk factors were analyzed by calculating the odds ratio in the procedure of logistic regression. Most often, the pathogens of the disease were Propionibacterium acnes (70.60%). The share of resistant strains was 91.66% with erythromycin, 91.25% with clindamycin, 96.64% with azithromycin, and 91.35% with laevomycetin (p<0.001). The highest sensitivity was observed for levofloxacin (96.74%) (p<0.001). Risk factors were smoking (OR=3.15; 95% CI: 0.57-2.61), disruptions of the hormonal-endocrine profile (OR=4.71; 95% CI: 2.43-5.12), being female (OR=1.41; 95% CI: 1.04-2.99), duration of disease over 5 years (OR=3.16; 95% CI: 1.67-4.03), and impractical antimicrobial therapy (OR=5.11; 95% CI: 3.17-6.15). Reducing the frequency of resistant forms requires rational prescription of antibacterial preparations, prescription delivery of antibiotics, and reduction of individual risk factors.
|Number of pages||4|
|Journal||Journal of Pharmaceutical Sciences and Research|
|Publication status||Published - Jun 1 2018|
- Propionibacterium acnes
- Resistant strains
ASJC Scopus subject areas
- Pharmaceutical Science