Reverse the resistance to PARP inhibitors

Yevgeniy Kim, Aleksei Kim, Ainur Sharip, Aigul Sharip, Juhong Jiang, Qing Yang, Yingqiu Xie

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment. Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. This paper describes several molecular mechanisms of PARPi resistance which were reported most recently, and summarizes some strategies to reverse this type of drug resistance.

Original languageEnglish
Pages (from-to)198-208
Number of pages11
JournalInternational Journal of Biological Sciences
Volume13
Issue number2
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • DNA repair
  • Drug resistance
  • PARP
  • PARP inhibitor

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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  • Cite this

    Kim, Y., Kim, A., Sharip, A., Sharip, A., Jiang, J., Yang, Q., & Xie, Y. (2017). Reverse the resistance to PARP inhibitors. International Journal of Biological Sciences, 13(2), 198-208. https://doi.org/10.7150/ijbs.17240