Reverse the resistance to PARP inhibitors

Yevgeniy Kim; Aleksei Kim; Ainur Sharip; Aigul Sharip; Juhong Jiang; Qing Yang; Yingqiu Xie

doi:10.7150/ijbs.17240

Reverse the resistance to PARP inhibitors

Yevgeniy Kim, Aleksei Kim, Ainur Sharip, Aigul Sharip, Juhong Jiang, Qing Yang, Yingqiu Xie

Department of Biology

Research output: Contribution to journal › Review article

34 Citations (Scopus)

Abstract

One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment. Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. This paper describes several molecular mechanisms of PARPi resistance which were reported most recently, and summarizes some strategies to reverse this type of drug resistance.

Original language	English
Pages (from-to)	198-208
Number of pages	11
Journal	International Journal of Biological Sciences
Volume	13
Issue number	2
DOIs	https://doi.org/10.7150/ijbs.17240
Publication status	Published - 2017

Keywords

DNA repair
Drug resistance
PARP
PARP inhibitor

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Applied Microbiology and Biotechnology
Molecular Biology
Developmental Biology
Cell Biology

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Kim, Y., Kim, A., Sharip, A., Sharip, A., Jiang, J., Yang, Q., & Xie, Y. (2017). Reverse the resistance to PARP inhibitors. International Journal of Biological Sciences, 13(2), 198-208. https://doi.org/10.7150/ijbs.17240

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AU - Sharip, Aigul

AU - Jiang, Juhong

AU - Yang, Qing

AU - Xie, Yingqiu

PY - 2017

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