TY - JOUR
T1 - Risk factors for primary pulmonary TB in Almaty Region, Kazakhstan
T2 - A matched case-control study
AU - Zhussupov, Baurzhan
AU - Hermosilla, Sabrina
AU - Terlikbayeva, Assel
AU - Aifah, Angela
AU - Ma, Xin
AU - Zhumadilov, Zhaxybay
AU - Abildayev, Tleukhan
AU - Darisheva, Meruyert
AU - Berikkhanova, Kulzhan
N1 - Funding Information:
The authors would like to thank the National Center for TB in Kazakhstan, the Center for Life Sciences at Nazarbayev University. Financial support for this study was provided by the Ministry of Education and Science of the Republic of Kazakhstan. The authors declare that there is no conflict of interests.
PY - 2016/4/27
Y1 - 2016/4/27
N2 - Background: This study examined the association between incident pulmonary tuberculosis (TB) and social and behavioral characteristics in Almaty Oblast, Kazakhstan from 2012 to 2013. Methods: We used a matched case-control design to estimate the role of factors for acquiring pulmonary TB. Totally 324 individuals were recruited from Sep 2012 to Mar 2013. Participants included 110 TB index cases with newly detected pulmonary TB. Each case was matched with one household and one community control. A total of 107 household and 107 community controls were included to the study. Adjusted odds ratios measuring associations between TB and risk factors were calculated by using a conditional multiple logistic regression analysis. Results: TB cases were more likely to be younger, recent smokers and have diabetes, when compared to household controls. Between TB cases and community controls, TB was significantly associated with age, non-married family status, living in a rented home, recent smoker, and having diabetes. Comparing TB cases with community controls, we found that foreign birth was marginally associated with incident TB case status. Conclusion: Our findings confirm the role of modifiable risk factors for TB in Kazakhstan; highlighting the importance of developing interventions addressing social determinants and proximate risk factors for high TB burden regions.
AB - Background: This study examined the association between incident pulmonary tuberculosis (TB) and social and behavioral characteristics in Almaty Oblast, Kazakhstan from 2012 to 2013. Methods: We used a matched case-control design to estimate the role of factors for acquiring pulmonary TB. Totally 324 individuals were recruited from Sep 2012 to Mar 2013. Participants included 110 TB index cases with newly detected pulmonary TB. Each case was matched with one household and one community control. A total of 107 household and 107 community controls were included to the study. Adjusted odds ratios measuring associations between TB and risk factors were calculated by using a conditional multiple logistic regression analysis. Results: TB cases were more likely to be younger, recent smokers and have diabetes, when compared to household controls. Between TB cases and community controls, TB was significantly associated with age, non-married family status, living in a rented home, recent smoker, and having diabetes. Comparing TB cases with community controls, we found that foreign birth was marginally associated with incident TB case status. Conclusion: Our findings confirm the role of modifiable risk factors for TB in Kazakhstan; highlighting the importance of developing interventions addressing social determinants and proximate risk factors for high TB burden regions.
KW - Kazakhstan
KW - Risk factors
KW - Tuberculosis
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M3 - Article
AN - SCOPUS:84974623104
VL - 45
SP - 441
EP - 450
JO - Iranian Journal of Public Health
JF - Iranian Journal of Public Health
SN - 0304-4556
IS - 4
ER -