Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy

A community based cohort study in Pakistan

Urooj Iftikhar, Syed Asad Ali, Shiyam Sunder Tikmani, Iqbal Azam, Sarah Saleem, Anita Kaniz Zaidi

Research output: Contribution to journalArticle

Abstract

Objective: To determine the safety of gentamicin when used in a community setting to treat neonatal sepsis. Methods: The study was conducted in peri-urban areas of Karachi from September 2009 to April 2010. The exposed group consisted of children 6 months to 3 years of age who were treated for sepsis during 0-2 months of age in the community, with a regimen that included gentamicin for at least five days. The control group included children from the same area who never received gentamicin. The outcome measure was hearing loss, which was assessed by Brainstem Evoked Response Audiometry. Results: Of the 255 children enrolled, 125 (49%) received gentamicin, while 130 (51%) were not exposed to gentamicin. Children in the gentamicin exposed group were not at increased risk for hearing loss compared to controls (n=30; 30.9% vs. n=33; 31.4%, RR 0.98; 95% CI: 0.60-1.61). Children with history of ear discharge (RR 1.7) and children with family history of deafness (RR 2.0) were more at risk for having hearing loss. Conclusion: No association was found between hearing loss and gentamicin exposure in a community setting for the management of sepsis in the first two months of life.

Original languageEnglish
Pages (from-to)1226-1229
Number of pages4
JournalJournal of the Pakistan Medical Association
Volume63
Issue number10
Publication statusPublished - Oct 2013
Externally publishedYes

Fingerprint

Pakistan
Gentamicins
Hearing Loss
Sepsis
Cohort Studies
Therapeutics
Evoked Response Audiometry
Deafness
Brain Stem
Ear
Outcome Assessment (Health Care)
Safety
Control Groups

Keywords

  • Aminoglycoside
  • Community management
  • Gentamicin
  • Neonate
  • Ototoxicity
  • Sepsis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy : A community based cohort study in Pakistan. / Iftikhar, Urooj; Ali, Syed Asad; Tikmani, Shiyam Sunder; Azam, Iqbal; Saleem, Sarah; Zaidi, Anita Kaniz.

In: Journal of the Pakistan Medical Association, Vol. 63, No. 10, 10.2013, p. 1226-1229.

Research output: Contribution to journalArticle

Iftikhar, Urooj ; Ali, Syed Asad ; Tikmani, Shiyam Sunder ; Azam, Iqbal ; Saleem, Sarah ; Zaidi, Anita Kaniz. / Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy : A community based cohort study in Pakistan. In: Journal of the Pakistan Medical Association. 2013 ; Vol. 63, No. 10. pp. 1226-1229.
@article{8f9a85dc67da4e14b25f067c6205b604,
title = "Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy: A community based cohort study in Pakistan",
abstract = "Objective: To determine the safety of gentamicin when used in a community setting to treat neonatal sepsis. Methods: The study was conducted in peri-urban areas of Karachi from September 2009 to April 2010. The exposed group consisted of children 6 months to 3 years of age who were treated for sepsis during 0-2 months of age in the community, with a regimen that included gentamicin for at least five days. The control group included children from the same area who never received gentamicin. The outcome measure was hearing loss, which was assessed by Brainstem Evoked Response Audiometry. Results: Of the 255 children enrolled, 125 (49{\%}) received gentamicin, while 130 (51{\%}) were not exposed to gentamicin. Children in the gentamicin exposed group were not at increased risk for hearing loss compared to controls (n=30; 30.9{\%} vs. n=33; 31.4{\%}, RR 0.98; 95{\%} CI: 0.60-1.61). Children with history of ear discharge (RR 1.7) and children with family history of deafness (RR 2.0) were more at risk for having hearing loss. Conclusion: No association was found between hearing loss and gentamicin exposure in a community setting for the management of sepsis in the first two months of life.",
keywords = "Aminoglycoside, Community management, Gentamicin, Neonate, Ototoxicity, Sepsis",
author = "Urooj Iftikhar and Ali, {Syed Asad} and Tikmani, {Shiyam Sunder} and Iqbal Azam and Sarah Saleem and Zaidi, {Anita Kaniz}",
year = "2013",
month = "10",
language = "English",
volume = "63",
pages = "1226--1229",
journal = "JPMA. The Journal of the Pakistan Medical Association",
issn = "0030-9982",
publisher = "Pakistan Medical Association",
number = "10",

}

TY - JOUR

T1 - Risk of hearing loss in children exposed to gentamicin for the treatment of sepsis in young infancy

T2 - A community based cohort study in Pakistan

AU - Iftikhar, Urooj

AU - Ali, Syed Asad

AU - Tikmani, Shiyam Sunder

AU - Azam, Iqbal

AU - Saleem, Sarah

AU - Zaidi, Anita Kaniz

PY - 2013/10

Y1 - 2013/10

N2 - Objective: To determine the safety of gentamicin when used in a community setting to treat neonatal sepsis. Methods: The study was conducted in peri-urban areas of Karachi from September 2009 to April 2010. The exposed group consisted of children 6 months to 3 years of age who were treated for sepsis during 0-2 months of age in the community, with a regimen that included gentamicin for at least five days. The control group included children from the same area who never received gentamicin. The outcome measure was hearing loss, which was assessed by Brainstem Evoked Response Audiometry. Results: Of the 255 children enrolled, 125 (49%) received gentamicin, while 130 (51%) were not exposed to gentamicin. Children in the gentamicin exposed group were not at increased risk for hearing loss compared to controls (n=30; 30.9% vs. n=33; 31.4%, RR 0.98; 95% CI: 0.60-1.61). Children with history of ear discharge (RR 1.7) and children with family history of deafness (RR 2.0) were more at risk for having hearing loss. Conclusion: No association was found between hearing loss and gentamicin exposure in a community setting for the management of sepsis in the first two months of life.

AB - Objective: To determine the safety of gentamicin when used in a community setting to treat neonatal sepsis. Methods: The study was conducted in peri-urban areas of Karachi from September 2009 to April 2010. The exposed group consisted of children 6 months to 3 years of age who were treated for sepsis during 0-2 months of age in the community, with a regimen that included gentamicin for at least five days. The control group included children from the same area who never received gentamicin. The outcome measure was hearing loss, which was assessed by Brainstem Evoked Response Audiometry. Results: Of the 255 children enrolled, 125 (49%) received gentamicin, while 130 (51%) were not exposed to gentamicin. Children in the gentamicin exposed group were not at increased risk for hearing loss compared to controls (n=30; 30.9% vs. n=33; 31.4%, RR 0.98; 95% CI: 0.60-1.61). Children with history of ear discharge (RR 1.7) and children with family history of deafness (RR 2.0) were more at risk for having hearing loss. Conclusion: No association was found between hearing loss and gentamicin exposure in a community setting for the management of sepsis in the first two months of life.

KW - Aminoglycoside

KW - Community management

KW - Gentamicin

KW - Neonate

KW - Ototoxicity

KW - Sepsis

UR - http://www.scopus.com/inward/record.url?scp=84884550514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884550514&partnerID=8YFLogxK

M3 - Article

VL - 63

SP - 1226

EP - 1229

JO - JPMA. The Journal of the Pakistan Medical Association

JF - JPMA. The Journal of the Pakistan Medical Association

SN - 0030-9982

IS - 10

ER -