Risk of malignancy index validity assessment in premenopausal and postmenopausal women with adnexal tumors

Milan Terzic, Jelena Dotlic, Ivana Likic, Natasa Brndusic, Igor Pilic, Nebojsa Ladjevic, Sanja Maricic, Nebojsa Arsenovic, Zoran Maricic

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Objective: The aim of this study was to investigate the validity of the risk of malignancy index (RMI) in premenopausal and postmenopausal patients with adnexal masses. Materials and Methods: The study involved all women treated for adnexal tumors throughout an 18-month period in the Clinic for Gynecology and Obstetrics, Clinical Center of Serbia (Belgrade, Serbia). On admission, detailed anamnestic and laboratory data were obtained and an expert ultrasound scan was performed. The RMI was calculated for all patients and the obtained data were related to histopathological findings of the tumors. For statistical analysis, we used descriptive and analytical statistics methods and an SPSS computer program. Results: From a total number of 540 women, 85 women had malignant tumors; 20 women, borderline tumors; and 435 women, benign adnexal tumors. The RMI was reliable in 84.6% of all patients; in 77% of premenopausal patients, and in 81.1% of postmenopausal patients. The sensitivity of the RMI in the overall population was 83.81%; the specificity was 77.24%; the positive predictive value (PPV) was 47.06%, and the negative predictive value (NPV) was 95.18%. In premenopausal women, the RMI sensitivity was 83.87%; specificity, 80.31%; PPV, 28.89%; and NPV, 98.12%. In postmenopausal women the RMI sensitivity was 83.78%; specificity, 68.18%; PPV, 63.92%; and NPV, 74.71%. Conclusion: The RMI was a reliable factor for differentiating benign from malignant adnexal masses in premenopausal and postmenopausal patients.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalTaiwanese Journal of Obstetrics and Gynecology
Issue number2
Publication statusPublished - Jun 1 2013
Externally publishedYes


  • Adnexal masses
  • Postmenopause
  • Premenopause
  • Risk of malignancy index

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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