Risk of reactivation of tuberculosis in the course of human immunodeficiency virus infection

G. Di Perri, R. Micciolo, S. Vento, M. Cruciani, S. Marocco, A. Carlotto, T. Adami, R. Mazzi, A. Cazzadori, E. Concia, D. Bassetti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: To establish, in a longitudinal study, whether reactivation of latent tuberculous infection takes place below an identifiable immunological threshold in subjects with human immunodeficiency virus (HIV) infection. Methods: We followed up for 2 years 44 subjects with HIV infection who had a positive intradermal reaction to tuberculin. All subjects were asymptomatic at enrollment. End points of the study were the development of active tuberculosis or the final evaluation (24 months since the beginning) for those who did not develop tuberculosis over the study period. Total lymphocyte count, CD4+ lymphocyte count and β-2 microglobulin serum levels were measured at baseline, during the period of observation (every 3-6 months) and at the end point. Multiple Antigen Skin Testing and purified protein derivative (PPD) testing were also performed at baseline and end point, as well as in intermediate phases of the study (every 6 and 12 months respectively). Results: Ten subjects (22.7%) developed tuberculosis during the study period. Both baseline and end point values of the parameters investigated differed significantly between subjects who developed tuberculosis and those who did not. Cox's model showed that total and CD4+ lymphocyte counts as well as β-2 microglobulin levels had a prognostic value at a univariate analysis; CD4+ and β-2 microglobulin retained statistical significance in a multivariate evaluation. CD4+ lymphocyte count was the parameter most strongly associated with the development of tuberculosis. Conclusions: Tuberculosis in this setting most often reactivates only when immune surveillance has fallen to an identifiable level. Planners of antituberculous chemoprophylactic policies should consider the downgrading tendancy of immune function in these subjects in order to choose the most appropriate time to intervene in the course of HIV infection. Starting prophylaxis in HIV-infected subjects only when CD4+ cells have dropped below the value of 500/mm3 seems to be a more fruitful option than the currently adopted strategy, which recommends time-limited (12 months) administration of daily isoniazid to all PPD+ HIV-infected subjects regardless their immunological status.

Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalEuropean Journal of Medicine
Volume2
Issue number5
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Virus Diseases
Tuberculosis
HIV
CD4 Lymphocyte Count
Lymphocyte Count
Human Immunodeficiency Virus Proteins
Tuberculin
Isoniazid
Proportional Hazards Models
Longitudinal Studies
Observation
Antigens
Skin
Infection
Serum
Proteins

Keywords

  • CD4+ lymphocytes
  • Chemoprophylaxis
  • Human immunodeficiency virus
  • Purified protein derivative
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Di Perri, G., Micciolo, R., Vento, S., Cruciani, M., Marocco, S., Carlotto, A., ... Bassetti, D. (1993). Risk of reactivation of tuberculosis in the course of human immunodeficiency virus infection. European Journal of Medicine, 2(5), 264-268.

Risk of reactivation of tuberculosis in the course of human immunodeficiency virus infection. / Di Perri, G.; Micciolo, R.; Vento, S.; Cruciani, M.; Marocco, S.; Carlotto, A.; Adami, T.; Mazzi, R.; Cazzadori, A.; Concia, E.; Bassetti, D.

In: European Journal of Medicine, Vol. 2, No. 5, 1993, p. 264-268.

Research output: Contribution to journalArticle

Di Perri, G, Micciolo, R, Vento, S, Cruciani, M, Marocco, S, Carlotto, A, Adami, T, Mazzi, R, Cazzadori, A, Concia, E & Bassetti, D 1993, 'Risk of reactivation of tuberculosis in the course of human immunodeficiency virus infection', European Journal of Medicine, vol. 2, no. 5, pp. 264-268.
Di Perri G, Micciolo R, Vento S, Cruciani M, Marocco S, Carlotto A et al. Risk of reactivation of tuberculosis in the course of human immunodeficiency virus infection. European Journal of Medicine. 1993;2(5):264-268.
Di Perri, G. ; Micciolo, R. ; Vento, S. ; Cruciani, M. ; Marocco, S. ; Carlotto, A. ; Adami, T. ; Mazzi, R. ; Cazzadori, A. ; Concia, E. ; Bassetti, D. / Risk of reactivation of tuberculosis in the course of human immunodeficiency virus infection. In: European Journal of Medicine. 1993 ; Vol. 2, No. 5. pp. 264-268.
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abstract = "Objectives: To establish, in a longitudinal study, whether reactivation of latent tuberculous infection takes place below an identifiable immunological threshold in subjects with human immunodeficiency virus (HIV) infection. Methods: We followed up for 2 years 44 subjects with HIV infection who had a positive intradermal reaction to tuberculin. All subjects were asymptomatic at enrollment. End points of the study were the development of active tuberculosis or the final evaluation (24 months since the beginning) for those who did not develop tuberculosis over the study period. Total lymphocyte count, CD4+ lymphocyte count and β-2 microglobulin serum levels were measured at baseline, during the period of observation (every 3-6 months) and at the end point. Multiple Antigen Skin Testing and purified protein derivative (PPD) testing were also performed at baseline and end point, as well as in intermediate phases of the study (every 6 and 12 months respectively). Results: Ten subjects (22.7{\%}) developed tuberculosis during the study period. Both baseline and end point values of the parameters investigated differed significantly between subjects who developed tuberculosis and those who did not. Cox's model showed that total and CD4+ lymphocyte counts as well as β-2 microglobulin levels had a prognostic value at a univariate analysis; CD4+ and β-2 microglobulin retained statistical significance in a multivariate evaluation. CD4+ lymphocyte count was the parameter most strongly associated with the development of tuberculosis. Conclusions: Tuberculosis in this setting most often reactivates only when immune surveillance has fallen to an identifiable level. Planners of antituberculous chemoprophylactic policies should consider the downgrading tendancy of immune function in these subjects in order to choose the most appropriate time to intervene in the course of HIV infection. Starting prophylaxis in HIV-infected subjects only when CD4+ cells have dropped below the value of 500/mm3 seems to be a more fruitful option than the currently adopted strategy, which recommends time-limited (12 months) administration of daily isoniazid to all PPD+ HIV-infected subjects regardless their immunological status.",
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AU - Micciolo, R.

AU - Vento, S.

AU - Cruciani, M.

AU - Marocco, S.

AU - Carlotto, A.

AU - Adami, T.

AU - Mazzi, R.

AU - Cazzadori, A.

AU - Concia, E.

AU - Bassetti, D.

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AB - Objectives: To establish, in a longitudinal study, whether reactivation of latent tuberculous infection takes place below an identifiable immunological threshold in subjects with human immunodeficiency virus (HIV) infection. Methods: We followed up for 2 years 44 subjects with HIV infection who had a positive intradermal reaction to tuberculin. All subjects were asymptomatic at enrollment. End points of the study were the development of active tuberculosis or the final evaluation (24 months since the beginning) for those who did not develop tuberculosis over the study period. Total lymphocyte count, CD4+ lymphocyte count and β-2 microglobulin serum levels were measured at baseline, during the period of observation (every 3-6 months) and at the end point. Multiple Antigen Skin Testing and purified protein derivative (PPD) testing were also performed at baseline and end point, as well as in intermediate phases of the study (every 6 and 12 months respectively). Results: Ten subjects (22.7%) developed tuberculosis during the study period. Both baseline and end point values of the parameters investigated differed significantly between subjects who developed tuberculosis and those who did not. Cox's model showed that total and CD4+ lymphocyte counts as well as β-2 microglobulin levels had a prognostic value at a univariate analysis; CD4+ and β-2 microglobulin retained statistical significance in a multivariate evaluation. CD4+ lymphocyte count was the parameter most strongly associated with the development of tuberculosis. Conclusions: Tuberculosis in this setting most often reactivates only when immune surveillance has fallen to an identifiable level. Planners of antituberculous chemoprophylactic policies should consider the downgrading tendancy of immune function in these subjects in order to choose the most appropriate time to intervene in the course of HIV infection. Starting prophylaxis in HIV-infected subjects only when CD4+ cells have dropped below the value of 500/mm3 seems to be a more fruitful option than the currently adopted strategy, which recommends time-limited (12 months) administration of daily isoniazid to all PPD+ HIV-infected subjects regardless their immunological status.

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