Robustness of Boolean dynamics under knockouts

Gunnar Boldhaus, Nils Bertschinger, Johannes Rauh, Eckehard Olbrich, Konstantin Klemm

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness. Here we study the effect of knockouts for binary state sequences and their implementations in terms of Boolean threshold networks. Besides random sequences with biologically plausible constraints, we analyze the cell cycle sequence of the species Saccharomyces cerevisiae and the Boolean networks implementing it. Comparing with an appropriate null model we do not find evidence that the yeast wildtype network is optimized for high knockout resilience. Our notion of knockout resilience weakly correlates with the size of the basin of attraction, which has also been considered a measure of robustness.

Original languageEnglish
Article number021916
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume82
Issue number2
DOIs
Publication statusPublished - Aug 18 2010

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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